Advertisement

Meningeal Lymphatic Vessels: A Drain of the Brain Involved in Neurodegeneration?

  • Yuan Cheng
  • Yan-Jiang WangEmail author
RESEARCH HIGHLIGHT

Neurodegenerative diseases include several kinds of neurological disorder that are caused by the progressive death of neurons in different regions of the brain. Such diseases affect millions of people worldwide and impose a heavy health burden on modern societies. However, their pathogenesis remains elusive, and disease-modifying methods are not currently available to prevent, halt, or reverse them [1]. A common feature of neurodegenerative diseases is that the abnormal accumulation of misfolded proteins, such as amyloid beta (Aβ), tau, α-synuclein, fused in sarcoma (FUS), and TAR DNA-binding protein 43 (TDP-43) in the brain leads to selective neuronal degeneration and dysfunction. Dysfunction in the removal of these misfolded proteins from the brain is thought to be a major cause of neurodegenerative diseases and a major therapeutic target for their cure.

Nearly all the tissues and organs, except for the central nervous system (CNS), have been found to include a lymphatic vasculature,...

Notes

Acknowledgements

This highlight was supported by the National Natural Science Foundation of China (91749206).

Conflict of interest

The authors declare no financial or other conflicts of interests.

References

  1. 1.
    Sun BL, Li WW, Zhu C, Jin WS, Zeng F, Liu YH, et al. Clinical research on Alzheimer’s disease: Progress and perspectives. Neurosci Bull 2018, 34: 1111–1118.CrossRefGoogle Scholar
  2. 2.
    Iliff JJ, Wang M, Liao Y, Plogg BA, Peng W, Gundersen GA, et al. A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid beta. Sci Transl Med 2012, 4: 147ra111.CrossRefGoogle Scholar
  3. 3.
    Aspelund A, Antila S, Proulx ST, Karlsen TV, Karaman S, Detmar M, et al. A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules. J Exp Med 2015, 212: 991–999.CrossRefGoogle Scholar
  4. 4.
    Louveau A, Smirnov I, Keyes TJ, Eccles JD, Rouhani SJ, Peske JD, et al. Structural and functional features of central nervous system lymphatic vessels. Nature 2015, 523: 337–341.CrossRefGoogle Scholar
  5. 5.
    Ahn JH, Cho H, Kim JH, Kim SH, Ham JS, Park I, et al. Meningeal lymphatic vessels at the skull base drain cerebrospinal fluid. Nature 2019, 572: 62–66.CrossRefGoogle Scholar
  6. 6.
    Xiang Y, Bu XL, Liu YH, Zhu C, Shen LL, Jiao SS, et al. Physiological amyloid-beta clearance in the periphery and its therapeutic potential for Alzheimer’s disease. Acta Neuropathol 2015, 130: 487–499.CrossRefGoogle Scholar
  7. 7.
    Wang J, Jin WS, Bu XL, Zeng F, Huang ZL, Li WW, et al. Physiological clearance of tau in the periphery and its therapeutic potential for tauopathies. Acta Neuropathol 2018, 136: 525–536.CrossRefGoogle Scholar
  8. 8.
    Da Mesquita S, Louveau A, Vaccari A, Smirnov I, Cornelison RC, Kingsmore KM, et al. Functional aspects of meningeal lymphatics in ageing and Alzheimer’s disease. Nature 2018, 560: 185–191.CrossRefGoogle Scholar
  9. 9.
    Wang J, Gu BJ, Masters CL, Wang YJ. A systemic view of Alzheimer disease—insights from amyloid-beta metabolism beyond the brain. Nat Rev Neurol 2017, 13: 612–623.CrossRefGoogle Scholar
  10. 10.
    Bu XL, Xiang Y, Jin WS, Wang J, Shen LL, Huang ZL, et al. Blood-derived amyloid-beta protein induces Alzheimer’s disease pathologies. Mol Psychiatry 2018, 23: 1948–1956.CrossRefGoogle Scholar

Copyright information

© Shanghai Institutes for Biological Sciences, CAS 2020

Authors and Affiliations

  1. 1.Department of Neurology and Center for Clinical Neuroscience, Daping HospitalThird Military Medical UniversityChongqingChina
  2. 2.Chongqing Key Laboratory of Aging and Brain DiseasesChongqingChina
  3. 3.The Institute of Brain and IntelligenceThird Military Medical UniversityChongqingChina

Personalised recommendations