Neuroscience Bulletin

, Volume 35, Issue 6, pp 1116–1119 | Cite as

Stay Active to Cope with Fear: A Cortico-Intrathalamic Pathway for Conditioned Flight Behavior

  • Ni Tang
  • Yi-Fan Ding
  • Wen Zhang
  • Ji Hu
  • Xiao-Hong XuEmail author

When facing fear-provoking situations, animals and humans alternate between active and passive coping responses [1]. Active coping such as flight or escape is thought to occur when animals perceive the situation to be controllable. In contrast, passive coping such as immobility or freezing is evoked if the situation is perceived to be inescapable. Previous studies have focused predominantly on the neural mechanisms underlying passive fear behaviors (or freezing) with very few published reports on the neural control of active fear responses (or flight). So, what are the neural mechanisms that regulate active fear responses and that permit flexible switching between passive and active coping strategies? A recent study published in Nature Neuroscience entitled “A novel cortico-intrathalamic circuit for flight behavior”, from Dr. Xiao-Ming Li’s lab at Zhejiang University, sheds new light on these important questions [2].

In this study, the authors adopted a new fear conditioning protocol...



This highlight was supported by grants from the National Natural Science Foundation of China (31871066), the National Basic Research Development Program (973 Program), Ministry of Science and Technology of China (2015CB559201), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB32000000), and in part by the open funds of the State Key Laboratory of Medical Neurobiology.


  1. 1.
    Keay KA, Bandler R. Parallel circuits mediating distinct emotional coping reactions to different types of stress. Neurosci Biobehav Rev 2001, 25: 669–678.CrossRefGoogle Scholar
  2. 2.
    Dong P, Wang H, Shen X, Jiang P, Zhu XF, Li Y, et al. A novel cortico-intrathalamic circuit for flight behavior. Nat Neurosci 2019, 22: 941–949.CrossRefGoogle Scholar
  3. 3.
    Fadok JP, Krabbe S, Markovic M, Courtin J, Xu C, Massi L, et al. A competitive inhibitory circuit for selection of active and passive fear responses. Nature 2017, 542: 96–100.CrossRefGoogle Scholar
  4. 4.
    Pinault D. The thalamic reticular nucleus: structure, function and concept. Brain Res Rev 2004, 46: 1–31.CrossRefGoogle Scholar
  5. 5.
    Crick F. Function of the thalamic reticular complex: the searchlight hypothesis. Proc Natl Acad Sci U S A 1984, 81: 4586–4590.CrossRefGoogle Scholar
  6. 6.
    Zhu Y, Jiang X, Ji W. The mechanism of cortico-striato-thalamo-cortical neurocircuitry in response inhibition and emotional responding in attention deficit hyperactivity disorder with comorbid disruptive behavior disorder. Neurosci Bull 2018, 34: 566–572.CrossRefGoogle Scholar
  7. 7.
    Wang Z, Liang S, Yu S, Xie T, Wang B, Wang J, et al. Distinct roles of dopamine receptors in the lateral thalamus in a rat model of decisional impulsivity. Neurosci Bull 2017, 33: 413–422.CrossRefGoogle Scholar
  8. 8.
    Wimmer RD, Schmitt LI, Davidson TJ, Nakajima M, Deisseroth K, Halassa MM. Thalamic control of sensory selection in divided attention. Nature 2015, 526: 705–709.CrossRefGoogle Scholar
  9. 9.
    Rikhye RV, Wimmer RD, Halassa MM. Toward an integrative theory of thalamic function. Ann Rev Neurosci 2018, 41: 163–183.CrossRefGoogle Scholar
  10. 10.
    Zhang W, Guo C, Chen D, Peng Q, Pan Y. Hierarchical control of Drosophila sleep, courtship, and feeding behaviors by male-specific P1 neurons. Neurosci Bull 2018, 34: 1105–1110.CrossRefGoogle Scholar

Copyright information

© Shanghai Institutes for Biological Sciences, CAS 2019

Authors and Affiliations

  1. 1.School of Life Sciences and TechnologyShangTech UniversityShanghaiChina
  2. 2.Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence TechnologyChinese Academy of SciencesShanghaiChina

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