Adult Neural Stem Cells: Constant Extension from Embryonic Ancestors
Adult neural stem cells (aNSCs) primarily exist in two regions: the subventricular zone (SVZ) of the lateral ventricle (LV) and the subgranular zone (SGZ) in the hippocampal dentate gyrus (DG) . It has been revealed that aNSCs in the SVZ (called type B cells) originate from embryonic NSCs mainly before embryonic day 15.5 (E15.5), and are set aside for postnatal neurogenesis after diverging [2, 3]. Whether this is the case with aNSCs in the hippocampus remains to be resolved . A prominent new study by Hongjun Song and colleagues showed that dentate NSCs from embryonic to adult stages share a common early origin, suggesting that neurogenesis in the hippocampus is a continuous process throughout development .
Dentate aNSCs continuously generate functionally integrated granule cells, which play critical roles in learning and memory, as well as mood regulation . Study of this process will help us better understand the functions of the hippocampus and repair its dysregulation in...
This highlight was supported by the grant from the National Natural Science Foundation of China (31600842).
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