Perspective on Etiology and Treatment of Bipolar Disorders in China: Clinical Implications and Future Directions

  • Zuowei Wang
  • Chen Jun
  • Keming Gao
  • Haichen Yang
  • Yiru FangEmail author

Bipolar disorder (BD) is a chronic, recurrent, disabling disease, even when given currently-available pharmacological and psychological treatments. Currently, the etiology and pathogenesis of BD remain unclear. As a consequence, patients with BD are frequently unrecognized, misdiagnosed, and inappropriately treated, which often yields a low treatment response and poor outcome. In the last decade or so, researchers in the fields of neuroscience and clinical psychiatry in China have worked together to explore the clinical phenomenology, etiology and pathogenesis of BD, and to investigate strategies for the treatment and management of BD. These efforts have not only moved researches in BD forward, but also have changed the practice of treating BD in China.

Etiology and Pathogenesis of BD

The available evidence supports the idea that the etiology of BD is multifactorial, including genetic loading, gene-gene, and gene-environment interactions [ 1]. The pathogenesis has been hypothesized as...



This insight article was supported by the National Key Research and Development Program of China (2016YFC1307100 and 2016YFC1307105), the Shanghai Key Medicine Specialties Program (ZK2015A06), Projects of International Cooperation and Exchanges National Natural Science Foundation of China (81761128032), and the Sanming Project of Medicine in Shenzhen, China (SZSM201612006).

Conflict of interest

The authors claim that there are no conflicts of interest.


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Copyright information

© Shanghai Institutes for Biological Sciences, CAS 2019

Authors and Affiliations

  1. 1.Division of Mood DisordersHongkou District Mental Health CenterShanghaiChina
  2. 2.Division of Mood DisordersShanghai Mental Health Center, Shanghai Jiao Tong University School of MedicineShanghaiChina
  3. 3.Case Western Reserve University School of MedicineClevelandUSA
  4. 4.Mood and Anxiety Clinic in the Mood Disorders Program of the Department of PsychiatryUniversity Hospital Cleveland Medical CenterClevelandUSA
  5. 5.Department of Mood DisordersShenzhen Mental Health CentreShenzhenChina
  6. 6.CAS Center for Excellence in Brain Science and Intelligence TechnologyShanghaiChina
  7. 7.Shanghai Key Laboratory of Psychotic DisordersShanghaiChina

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