Autonomic Nervous Function in Vasovagal Syncope of Children and Adolescents

  • Chunyan Tao
  • Chaoshu Tang
  • Selena Chen
  • Hongfang JinEmail author
  • Junbao DuEmail author

Syncope is defined as a transient loss of consciousness due to global cerebral hypoperfusion, accompanied by loss of muscle tone and failure to maintain an active position. Vasovagal syncope (VVS) is the most common presentation of syncope, and its diagnostic criteria include: (1) absence of any other evident etiology for syncope or pre-syncope, (2) positive response to head-up tilt test with evident vasovagal reaction (hypotension and/or bradycardia), and (3) no concomitant chronic or acute disease [1, 2]. The onset of VVS peaks initially in childhood and adolescence, and accounts for 60%–70% of all syncopal cases. Clinicians pay great attention to syncope among children and adolescents, due to its high prevalence and its impact on patients’ quality of life. Affected individuals often experience mental stress, economic burdens, and accidental bodily injuries related to syncope [2]. While the pathogenesis of VVS is not fully understood, autonomic nervous dysfunction has been...



This insight was supported by the Science and Technology Program of Beijing Municipality, China (Z171100001017253) and Peking University Clinical Scientist Program, China (BMU2019LCKXJ001).


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Copyright information

© Shanghai Institutes for Biological Sciences, CAS 2019

Authors and Affiliations

  1. 1.Department of PediatricsPeking University First HospitalBeijingChina
  2. 2.Department of Physiology and PathophysiologyPeking University Health Sciences CentreBeijingChina
  3. 3.Division of Biological SciencesUniversity of CaliforniaSan DiegoUSA
  4. 4.Key Laboratory of Molecular Cardiovascular SciencesMinistry of Education of ChinaBeijingChina

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