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The Secret of Fear Memory Attenuation: Facing Fears

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References

  1. Schiller D, Monfils MH, Raio CM, Johnson DC, Ledoux JE, Phelps EA. Preventing the return of fear in humans using reconsolidation update mechanisms. Nature 2010, 463: 49–53.

    Article  CAS  PubMed  Google Scholar 

  2. Craske MG, Treanor M, Conway CC, Zbozinek T, Vervliet B. Maximizing exposure therapy: an inhibitory learning approach. Behav Res Ther 2014, 58: 10–23.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Tonegawa S, Liu X, Ramirez S, Redondo R. Memory Engram Cells Have Come of Age. Neuron 2015, 87: 918–931.

    Article  CAS  PubMed  Google Scholar 

  4. Denny CA, Kheirbek MA, Alba EL, Tanaka KF, Brachman RA, Laughman KB, et al. Hippocampal memory traces are differentially modulated by experience, time, and adult neurogenesis. Neuron 2014, 83: 189–201.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Liu X, Ramirez S, Pang PT, Puryear CB, Govindarajan A, Deisseroth K, et al. Optogenetic stimulation of a hippocampal engram activates fear memory recall. Nature 2012, 484: 381–385.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Reijmers LG, Perkins BL, Matsuo N, Mayford M. Localization of a stable neural correlate of associative memory. Science 2007, 317: 1230–1233.

    Article  CAS  PubMed  Google Scholar 

  7. Khalaf O, Resch S, Dixsaut L, Gorden V, Glauser L, Gräff J. Reactivation of recall-induced neurons contributes to remote fear memory attenuation. Science 2018, 360: 1239–1242.

    Article  CAS  PubMed  Google Scholar 

  8. Pickens CL, Golden SA, Adams-Deutsch T, Nair SG, Shaham Y. Long-lasting incubation of conditioned fear in rats. Biol Psychiatry 2009, 65: 881–886.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Graff J, Joseph NF, Horn ME, Samiei A, Meng J, Seo J, et al. Epigenetic priming of memory updating during reconsolidation to attenuate remote fear memories. Cell 2014, 156: 261–276.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Auchter AM, Shumake J, Gonzalez-Lima F, Monfils MH. Preventing the return of fear using reconsolidation updating and methylene blue is differentially dependent on extinction learning. Sci Rep 2017, 7: 46071.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Monfils MH, Cowansage KK, Klann E, LeDoux JE. Extinction-reconsolidation boundaries: key to persistent attenuation of fear memories. Science 2009, 324: 951–955.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Abdou K, Shehata M, Choko K, Nishizono H, Matsuo M, Muramatsu SI, et al. Synapse-specific representation of the identity of overlapping memory engrams. Science 2018, 360: 1227–1231.

    Article  CAS  PubMed  Google Scholar 

  13. Han SL, Xu TL. Unraveling the Mechanisms of Memory Extinction. Neurosci Bull 2018, 34: 385–388.

    Article  CAS  PubMed  Google Scholar 

  14. Myers KM, Davis M. Mechanisms of fear extinction. Mol Psychiatry 2007, 12: 120–150.

    Article  CAS  PubMed  Google Scholar 

  15. Ramirez S, Liu X, Lin PA, Suh J, Pignatelli M, Redondo RL, et al. Creating a false memory in the hippocampus. Science 2013, 341: 387–391.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. School of Psychology, Nanjing Normal University, Nanjing, 210097, China

    Yan-Chen Guo & Ben-Yu Guo

  2. Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China

    Tifei Yuan

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  1. Yan-Chen Guo
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  2. Tifei Yuan
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  3. Ben-Yu Guo
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Correspondence to Tifei Yuan or Ben-Yu Guo.

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Guo, YC., Yuan, T. & Guo, BY. The Secret of Fear Memory Attenuation: Facing Fears. Neurosci. Bull. 35, 775–777 (2019). https://doi.org/10.1007/s12264-019-00380-x

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  • DOI: https://doi.org/10.1007/s12264-019-00380-x

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