A Novel Prognostic Approach to Predict Recovery in Patients with Chronic Disorders of Consciousness

  • Wangxiao Bao
  • Xiaoxia Li
  • Benyan LuoEmail author

Severe brain injury can lead to acute or chronic disorders of consciousness (DOC), and the latter represents a more critical challenge in diagnosis and management. For most chronic unconsciousness survivors with preserved sleep-wake cycles, including vegetative state (VS) and minimally conscious state (MCS), levels of consciousness are commonly monitored and determined based on behavioral evidence. VS, also termed unresponsive wakefulness syndrome (UWS), is characterized by complete absence of awareness and may be associated with poor recovery, while MCS exhibit discernible behavioral signs of environmental or self- awareness [1]. Since nearly 40% patients in MCS are initially misdiagnosed as VS/UWS due to the limitation of the existing diagnostic criterion, it is therefore necessary to define the accurate diagnostic and prognostic categorization for long-term outcome [2].

Chronic disorders of consciousness are mainly caused by traumatic or vascular brain injury, with a VS prevalence...



This Research Highlight was supported by grants from National Natural Science Foundation of China (81870817, and 81671143), the Science and Technology Plan of Zhejiang Province, China (2017C03011).


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Copyright information

© Shanghai Institutes for Biological Sciences, CAS 2019

Authors and Affiliations

  1. 1.Department of Neurology, First Affiliated Hospital, Collaborative Innovation Center for Brain ScienceZhejiang University School of MedicineHangzhouChina

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