Therapeutic Potential of Glucagon-Like Peptide-1 Cleavage Product for Alzheimer’s Disease

  • Stephen M. Day
  • Tao MaEmail author

Alzheimer’s disease (AD) is a devastating neurodegenerative disease and the most common form of dementia in the elderly. Concurrent with an aging population, the incidence of AD has been rising steadily and become a global threat to public health [1]. Unfortunately, there are currently no effective interventions that can cure AD or slow its progression, and recently finished clinical trials targeting brain amyloid-β (Aβ) accumulation have not succeeded in improving cognitive impairments in AD patients [1]. Thus, it is necessary and urgent to identify alternative disease-modifying strategies to alleviate AD pathophysiology. In this perspective article, we focus on glucagon-like peptide-1 (GLP-1), specifically its natural cleavage product GLP-1 (9-36), as a potential therapeutic approach for AD.

Biology of GLP-1

GLP-1 is an incretin hormone released from the L-cells of the distal ileum in response to nutrient ingestion. This proglucagon protein is a prohormone which gives rise to several...



This insight was supported by the National Institutes of Health, USA (K99/R00 AG044469, R01 AG055581, and R01 AG056622), and the BrightFocus Foundation (A2017457S).

Conflict of interest

The authors declare no conflict of interest.


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Copyright information

© Shanghai Institutes for Biological Sciences, CAS 2019

Authors and Affiliations

  1. 1.Department of Internal Medicine, Gerontology and Geriatric MedicineWake Forest School of MedicineWinston-SalemUSA
  2. 2.Department of Physiology and PharmacologyWake Forest School of MedicineWinston-SalemUSA
  3. 3.Department of Neurobiology and AnatomyWake Forest School of MedicineWinston-SalemUSA

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