The Mitochondrion: A Potential Therapeutic Target for Alzheimer’s Disease
The mitochondrion is a double-membrane organelle consisting of an outer membrane, intermembrane space, inner membrane, cristae, and matrix. It is the “energy plant” that provides most of the energy for cells. Mitochondria also participate in various processes such as calcium homeostasis, cell death, and cell growth during development and aging . Mitochondrial abnormalities are a common phenomenon in aging and age-related neurodegenerative diseases such as Alzheimer’s disease (AD). Mitochondrial dysfunction is even taken to be a marker for aging, an indispensable risk factor for AD . Anti-oxidants and factors that maintain mitochondrial homeostasis have beneficial effects in AD therapy. Thus, the mitochondrion is emerging as a novel target for AD therapy.
Mitochondrial Dysfunction is an Early and Common Feature of AD
AD is a neurodegenerative disease characterized by deficits in learning, memory, and other cognitive functions. Its major pathological characteristics...
This perspective article was supported by the National Natural Science Foundation of China (81870897, 81671111, and 81601111), the Natural Science Foundation of Jiangsu Province, China (BK20181436), the Priority Academic Program Development of Jiangsu Higher Education Institutions, the Suzhou Clinical Research Center of Neurological Disease (Szzx201503), a Jiangsu Provincial Medical Key Discipline Project (ZDXKB2016022), the Jiangsu Provincial Special Program of Medical Science (BL2014042), and the Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases (BM2013003).
Conflict of interest
The authors have no conflicting financial interests.
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