Neuroscience Bulletin

, Volume 35, Issue 2, pp 365–368 | Cite as

Parkinson’s Disease Risk Variant rs1109303 Regulates the Expression of INPP5K and CRK in Human Brain

  • Guiyou Liu
  • Yi Zhao
  • Jing-yi Sun
  • Bao-liang SunEmail author
Letter to the Editor

Dear Editor,

Parkinson’s disease (PD) is the second most common neurodegenerative disease in the elderly [1, 2]. PD affects 1%–2% of the world’s population older than 65 years [3, 4, 5]. In recent years, large-scale genome-wide association studies (GWAS) have been widely conducted to identify the common genetic risk genes for PD. A number of PD susceptibility genes have been identified, including SNCA, MAPT, NUCKS1, the HLA region, GAK, BST1, GBA, WNT3, RIT2, and LRRK2 [3, 4, 5].

It has been reported that the serum urate level is associated with PD risk and progression [6]. In 2015, Nazeri et al. conducted a GWAS and highlighted an association of the rs1109303 variant (T > G) within an intronic region of the INPP5K gene with the serum urate level (P = 2.01E-08) [6]. The authors considered that the rs1109303 variant may impact PD progression by affecting the expression of nearby genes (MYO1C, PITPNA, SLC43A2, and CRK) [6], but they did not directly investigate this association, which...



This work was supported in part by the National Natural Science Foundation of China (81471212) and the Taishan Scholar Project to BLS.

Compliance with Ethical Standards

Competing financial interests

The authors declare no competing financial interests.


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Copyright information

© Shanghai Institutes for Biological Sciences, CAS and Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  • Guiyou Liu
    • 1
    • 2
  • Yi Zhao
    • 3
  • Jing-yi Sun
    • 4
  • Bao-liang Sun
    • 1
    Email author
  1. 1.Key Laboratory of Cerebral Microcirculation in Universities of Shandong, Department of NeurologyAffiliated Hospital of Taishan Medical CollegeTaianChina
  2. 2.School of Life Science and TechnologyHarbin Institute of TechnologyHarbinChina
  3. 3.Affiliated HospitalTaishan Medical UniversityTaianChina
  4. 4.Wonju Severance Christian Hospital, Wonju College of MedicineYonsei UniversityWonjuKorea

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