References
Sikirić P, Petek M, Rucman R, Seiwerth S, Grabarević Z, Rotkvić I, et al. A new gastric juice peptide, BPC-An overview of stomach/stress/organoprotection hypothesis and BPC beneficial effects. J Physiol (Paris) 1993, 87: 313–327.
Sikiric P, Seiwerth S, Grabarevic Z, Petek M, Rucman R, Turkovic B, et al. The beneficial effect of BPC 157, a 15 amino acid peptide BPC fragment, on gastric and duodenal lesions induced by restraint stress, cysteaniune and 96% ethanol in rats. A comparative study with H2 receptor antagonists, dopaunine promoters and gut peptides. Life Sci 1994, 54: PL63–68.
Linan-Rico A, Ochoa-Cortes F, Beyder A, Soghomonyan S, Zuleta-Alarcon A, Coppola V, et al. Mechanosensory signaling in enterochromaffin cells and 5-HT release: potential implications for gut inflammation. Front Neurosci 2016, 10: 564.
Gershon MD, Tack J. The serotonin signaling system: from basic understanding to drug development for functional GI disorders. Gastroenterology 2007, 132: 397–414.
Wood JD. Enteric nervous system neuropathy: repair and restoration. Curr Opin Gastroenterol 2011, 27: 106–111.
Gershon MD. Serotonin is a sword and a shield of the bowel: serotonin plays offense and defense. Trans Am Clin Climatol Assoc 2012, 123: 268–280.
Smith TK, Gershon MD. Cross Talk proposal: 5-HT is necessary for peristalsis. J Physiol 2015, 593: 3225–3227.
Boban Blagaic A, Blagaic V, Mirt M, Jelovac N, Dodig G, Rucman R, et al. Gastric pentadecapeptideBPC 157 effective against serotonin syndrome in rats. Eur J Pharmacol 2005, 512: 173–179.
Tohyama Y, Sikirić P, Diksic M. Effects of pentadecapeptide BPC157 on regional serotonin synthesis in the rat brain: alphamethyl-l-tryptophan autoradiographic measurements. Life Sci 2004, 76: 345–357.
Sikiric P, Seiwerth S, Rucman R, Kolenc D, Vuletic LB, Drmic D, et al. Brain-gut axis and pentadecapeptide BPC 157: Theoretical and practical implications. Curr Neuropharmacol 2016, 14: 857–865.
Sikiric P, Seiwerth S, Rucman R, Turkovic B, Rokotov DS, Brcic L, et al. Stable gastric pentadecapeptide BPC 157: novel therapy in gastrointestinal tract. Curr Pharm Des 2011, 17: 1612–1632.
Cirillo C, Vanden BP, Tack J. Role of serotonin in gastrointestinal physiology and pathology. Minerva Endocrinol 2011, 36: 311–324.
Acknowledgments
We appreciate very much the gift of BPC157 from Dr. Predrag Sikiric in Zagreb, Croatia. This work was supported by a JMEY International collaboration Grant (020002015).
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Wang, XY., Qu, M., Duan, R. et al. Cytoprotective Mechanism of the Novel Gastric Peptide BPC157 in Gastrointestinal Tract and Cultured Enteric Neurons and Glial Cells. Neurosci. Bull. 35, 167–170 (2019). https://doi.org/10.1007/s12264-018-0269-8
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DOI: https://doi.org/10.1007/s12264-018-0269-8