Cytoprotective Mechanism of the Novel Gastric Peptide BPC157 in Gastrointestinal Tract and Cultured Enteric Neurons and Glial Cells
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Body protection compound (BPC) 157 is a stable gastric pentadecapeptide. Predrag Sikiric’s team has carried out many investigations of its cytoprotective effects in different organs and tissues [1, 2]. Their evidence indicates that BPC157 has potent cytoprotection in neural injury and gastrointestinal (GI) ulcers. Nevertheless, the effects of BPC157 in the GI remain unclear. It is well known that the gut produces 95% of the 5-hydroxytryptamine (5-HT) in the human body. The 5-HT in the intestinal mucosa stimulates the production of pro-inflammatory mediators by immune cells. Enteric 5-HT may be a key player in physiological actions and the pathogenesis of intestinal inflammation [3, 4, 5]. Previous evidence has shown that enteric 5-HT plays a prominent role in inflammatory bowel disease [6, 7]. The reports imply that BPC157 significantly modulates the regional synthesis of 5-HT in different areas of the rat brain [8, 9]. So far, the detailed mechanism of action of BPC157...
We appreciate very much the gift of BPC157 from Dr. Predrag Sikiric in Zagreb, Croatia. This work was supported by a JMEY International collaboration Grant (020002015).
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