Neuroscience Bulletin

, Volume 34, Issue 6, pp 1111–1118 | Cite as

Clinical Research on Alzheimer’s Disease: Progress and Perspectives

  • Bin-Lu Sun
  • Wei-Wei Li
  • Chi Zhu
  • Wang-Sheng Jin
  • Fan Zeng
  • Yu-Hui Liu
  • Xian-Le Bu
  • Jie Zhu
  • Xiu-Qing YaoEmail author
  • Yan-Jiang WangEmail author


Alzheimer’s disease (AD), the most common type of dementia, is becoming a major challenge for global health and social care. However, the current understanding of AD pathogenesis is limited, and no early diagnosis and disease-modifying therapy are currently available. During the past year, significant progress has been made in clinical research on the diagnosis, prevention, and treatment of AD. In this review, we summarize the latest achievements, including diagnostic biomarkers, polygenic hazard score, amyloid and tau PET imaging, clinical trials targeting amyloid-beta (Aβ), tau, and neurotransmitters, early intervention, and primary prevention and systemic intervention approaches, and provide novel perspectives for further efforts to understand and cure the disease.


Alzheimer’s disease Amyloid-beta Tau Immunotherapy BACE1 inhibitor 5-HT6 receptor antagonist Primary prevention Positron emission tomographic imaging Biomarker 



This review was supported by the the Chinese Ministry of Science and Technology (2016YFC1306401).

Compliance with Ethical Standards

Conflict of interest

All authors claim that there are no conflicts of interest.


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Copyright information

© Shanghai Institutes for Biological Sciences, CAS and Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  • Bin-Lu Sun
    • 1
  • Wei-Wei Li
    • 1
  • Chi Zhu
    • 1
  • Wang-Sheng Jin
    • 1
  • Fan Zeng
    • 1
  • Yu-Hui Liu
    • 1
  • Xian-Le Bu
    • 1
  • Jie Zhu
    • 1
  • Xiu-Qing Yao
    • 1
    Email author
  • Yan-Jiang Wang
    • 1
    • 2
    Email author
  1. 1.Department of NeurologyDaping Hospital, Third Military Medical UniversityChongqingChina
  2. 2.State Key Laboratory of Trauma, Burn and Combined InjuryInstitute of Surgery Research, Daping Hospital, Third Military Medical UniversityChongqingChina

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