Clinical Research on Alzheimer’s Disease: Progress and Perspectives
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Alzheimer’s disease (AD), the most common type of dementia, is becoming a major challenge for global health and social care. However, the current understanding of AD pathogenesis is limited, and no early diagnosis and disease-modifying therapy are currently available. During the past year, significant progress has been made in clinical research on the diagnosis, prevention, and treatment of AD. In this review, we summarize the latest achievements, including diagnostic biomarkers, polygenic hazard score, amyloid and tau PET imaging, clinical trials targeting amyloid-beta (Aβ), tau, and neurotransmitters, early intervention, and primary prevention and systemic intervention approaches, and provide novel perspectives for further efforts to understand and cure the disease.
KeywordsAlzheimer’s disease Amyloid-beta Tau Immunotherapy BACE1 inhibitor 5-HT6 receptor antagonist Primary prevention Positron emission tomographic imaging Biomarker
This review was supported by the the Chinese Ministry of Science and Technology (2016YFC1306401).
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Conflict of interest
All authors claim that there are no conflicts of interest.
- 13.Fandos N, Perez-Grijalba V, Pesini P, Olmos S, Bossa M, Villemagne VL, et al. Plasma amyloid beta 42/40 ratios as biomarkers for amyloid beta cerebral deposition in cognitively normal individuals. Alzheimers Dement (Amst) 2017, 8: 179–187.Google Scholar
- 41.Wilcock GK, Gauthier S, Frisoni GB, Jia J, Hardlund JH, Moebius HJ, et al. Potential of low dose leuco-methylthioninium bis(hydromethanesulphonate) (LMTM) monotherapy for treatment of mild Alzheimer’s disease: cohort analysis as modified primary outcome in a phase III clinical trial. J Alzheimers Dis 2018, 61: 435–457.CrossRefGoogle Scholar