Cystatin C Induces Insulin Resistance in Hippocampal Neurons and Promotes Cognitive Dysfunction in Rodents
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Cognitive impairment is a hallmark of neurodegenerative disorders such as Alzheimer’s disease (AD) and Parkinson’s disease. Growing evidence has demonstrated that cognitive impairment is closely associated with insulin resistance. For instance, the risk of AD is increased in diabetic patients . Moreover, cognitively impaired persons exhibit high levels of fasting glucose and fasting insulin, elevated Homeostasis Model Assessment, an impaired insulin response to glucose, and increased frequency of diabetes. In accord with this, intranasal insulin administration greatly improves the delayed memory and caregiver-rated functional ability of patients with amnestic mild cognitive impairment or AD .
Cystatin C (CysC) is a ubiquitously-expressed protein and an inhibitor of cysteine protease. It has been demonstrated that plasma CysC is a positive indicator of central adiposity and insulin resistance . Recently, a clinical survey indicated that a higher titer of plasma...
This work was supported by the National Natural Science Foundation of China (81471037 and 81770841); the “Six Kinds of Talents Summit” of Jiangsu Province, China (SWYY-051); Basic Research Program of Education Department of Jiangsu Province, China (14KJA180006); the Program for New Technology of Clinical Diagnosis and Treatment at Nantong (MS22016024); Priority Academic Development Program of Jiangsu Higher Education Institutions.
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All authors claim that there are no conflicts of interest.
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