Neuroscience Bulletin

, Volume 34, Issue 5, pp 789–800 | Cite as

Development of an Autism Subtyping Questionnaire Based on Social Behaviors

  • Fan-Chao Meng
  • Xin-Jie Xu
  • Tian-Jia Song
  • Xiao-Jing Shou
  • Xiao-Li Wang
  • Song-Ping Han
  • Ji-Sheng Han
  • Rong Zhang
Original Article


Autism spectrum disorder can be differentiated into three subtypes (aloof, passive, and active-but-odd) based on social behaviors according to the Wing Subgroups Questionnaire (WSQ). However, the correlations between the scores on some individual items and the total score are poor. In the present study, we translated the WSQ into Chinese, modified it, validated it in autistic and typically-developing Chinese children, and renamed it the Beijing Autism Subtyping Questionnaire (BASQ). Our results demonstrated that the BASQ had improved validity and reliability, and differentiated autistic children into these three subtypes more precisely. We noted that the autistic symptoms tended to be severe in the aloof, moderate in the passive, and mild in the active-but-odd subtypes. The modified questionnaire may facilitate etiological studies and the selection of therapeutic regimes.


Autism spectrum disorder Subtypes Wing Subgroups Questionnaire Beijing Autism Subtyping Questionnaire 



This work was supported by the grant from the University of Ulm–Peking University Health Science Center Joint Center for Neuroscience Fund (BMU20160563) and the grant from the National Natural Science Foundation of China (81601196).

Compliance with Ethical Standards

Conflict of interest

The authors declare that they have no conflict of interest.

Supplementary material

12264_2018_224_MOESM1_ESM.pdf (15 kb)
Supplementary material 1 (PDF 16 kb)


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Copyright information

© Shanghai Institutes for Biological Sciences, CAS and Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  • Fan-Chao Meng
    • 1
    • 2
    • 3
    • 4
  • Xin-Jie Xu
    • 5
  • Tian-Jia Song
    • 1
    • 2
    • 3
    • 4
  • Xiao-Jing Shou
    • 1
    • 2
    • 3
    • 4
  • Xiao-Li Wang
    • 6
  • Song-Ping Han
    • 7
  • Ji-Sheng Han
    • 1
    • 2
    • 3
    • 4
  • Rong Zhang
    • 1
    • 2
    • 3
    • 4
  1. 1.Neuroscience Research InstitutePeking UniversityBeijingChina
  2. 2.Key Laboratory for Neuroscience, Ministry of Education of ChinaPeking UniversityBeijingChina
  3. 3.Key Laboratory for Neuroscience, National Committee of Health and Family Planning of ChinaPeking UniversityBeijingChina
  4. 4.Department of Neurobiology, School of Basic Medical SciencesPeking UniversityBeijingChina
  5. 5.Central Laboratory, Research Center for Translational Medicine, Department of Scientific Research, Peking Union Medical College HospitalChinese Academy of Medical Science and Peking Union Medical CollegeBeijingChina
  6. 6.Division of Maternal and Child Health, School of Public HealthPeking University Health Science CenterBeijingChina
  7. 7.Wuxi Shenpingxintai Medical Technology Co., Ltd.WuxiChina

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