ZNF804A Variation May Affect Hippocampal-Prefrontal Resting-State Functional Connectivity in Schizophrenic and Healthy Individuals
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The ZNF804A variant rs1344706 has consistently been associated with schizophrenia and plays a role in hippocampal-prefrontal functional connectivity during working memory. Whether the effect exists in the resting state and in patients with schizophrenia remains unclear. In this study, we investigated the ZNF804A polymorphism at rs1344706 in 92 schizophrenic patients and 99 healthy controls of Han Chinese descent, and used resting-state functional magnetic resonance imaging to explore the functional connectivity in the participants. We found a significant main effect of genotype on the resting-state functional connectivity (RSFC) between the hippocampus and the dorsolateral prefrontal cortex (DLPFC) in both schizophrenic patients and healthy controls. The homozygous ZNF804A rs1344706 genotype (AA) conferred a high risk of schizophrenia, and also exhibited significantly decreased resting functional coupling between the left hippocampus and right DLPFC (F(2,165) = 13.43, P < 0.001). The RSFC strength was also correlated with cognitive performance and the severity of psychosis in schizophrenia. The current findings identified the neural impact of the ZNF804A rs1344706 on hippocampal-prefrontal RSFC associated with schizophrenia.
KeywordsSchizophrenia ZNF804A Imaging genetics Hippocampus Dorsolateral prefrontal cortex
This work was supported by the National Key Research and Development Program of China (2016YFC1307000 and 2015BAI13B01), the National Natural Science Foundation of China (91432304, 81370032, 81571313 and 81221002), Capital Health Development Research (2016-2-4112), and Beijing Nova Program Interdisciplinary Studies Cooperative Project (Z161100004916038). We thank the Department of Radiology, The Third Hospital, Peking University, for providing the equipment for neuroimaging. We thank all the participants in this study.
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Conflict of interest
All authors claim that there are no conflicts of interest.
- 26.Strauss E, Sherman EM, Spreen O. A Compendium of Neuropsychological Tests: Administration, Norms, and Commentary. Oxford University Press, 2006.Google Scholar
- 27.Wechsler D. WAIS-III, Wechsler Adult Intelligence Scale: Administration and Scoring Manual. Psychological Corporation, 1997.Google Scholar
- 28.Wechsler D. WMS-R: Wechsler memory scale-revised: manual. Psychological Corporation, 1984.Google Scholar
- 41.Plaschke RN, Cieslik EC, Muller VI, Hoffstaedter F, Plachti A, Varikuti DP, et al. On the integrity of functional brain networks in schizophrenia, Parkinson’s disease, and advanced age: Evidence from connectivity-based single-subject classification. Hum Brain Mapp 2017, 38: 5845–5858.CrossRefPubMedGoogle Scholar
- 60.Tao R, Cousijn H, Jaffe AE, Burnet PW, Edwards F, Eastwood SL, et al. Expression of ZNF804A in human brain and alterations in schizophrenia, bipolar disorder, and major depressive disorder: a novel transcript fetally regulated by the psychosis risk variant rs1344706. JAMA Psychiatry 2014, 71: 1112–1120.CrossRefPubMedPubMedCentralGoogle Scholar