Neuroscience Bulletin

, Volume 34, Issue 3, pp 507–516 | Cite as

ZNF804A Variation May Affect Hippocampal-Prefrontal Resting-State Functional Connectivity in Schizophrenic and Healthy Individuals

  • Yuyanan Zhang
  • Hao Yan
  • Jinmin Liao
  • Hao Yu
  • Sisi Jiang
  • Qi Liu
  • Dai Zhang
  • Weihua Yue
Original Article


The ZNF804A variant rs1344706 has consistently been associated with schizophrenia and plays a role in hippocampal-prefrontal functional connectivity during working memory. Whether the effect exists in the resting state and in patients with schizophrenia remains unclear. In this study, we investigated the ZNF804A polymorphism at rs1344706 in 92 schizophrenic patients and 99 healthy controls of Han Chinese descent, and used resting-state functional magnetic resonance imaging to explore the functional connectivity in the participants. We found a significant main effect of genotype on the resting-state functional connectivity (RSFC) between the hippocampus and the dorsolateral prefrontal cortex (DLPFC) in both schizophrenic patients and healthy controls. The homozygous ZNF804A rs1344706 genotype (AA) conferred a high risk of schizophrenia, and also exhibited significantly decreased resting functional coupling between the left hippocampus and right DLPFC (F(2,165) = 13.43, P < 0.001). The RSFC strength was also correlated with cognitive performance and the severity of psychosis in schizophrenia. The current findings identified the neural impact of the ZNF804A rs1344706 on hippocampal-prefrontal RSFC associated with schizophrenia.


Schizophrenia ZNF804A Imaging genetics Hippocampus Dorsolateral prefrontal cortex 



This work was supported by the National Key Research and Development Program of China (2016YFC1307000 and 2015BAI13B01), the National Natural Science Foundation of China (91432304, 81370032, 81571313 and 81221002), Capital Health Development Research (2016-2-4112), and Beijing Nova Program Interdisciplinary Studies Cooperative Project (Z161100004916038). We thank the Department of Radiology, The Third Hospital, Peking University, for providing the equipment for neuroimaging. We thank all the participants in this study.

Compliance with Ethical Standards

Conflict of interest

All authors claim that there are no conflicts of interest.

Supplementary material

12264_2018_221_MOESM1_ESM.pdf (415 kb)
Supplementary material 1 (PDF 404 kb)


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Copyright information

© Shanghai Institutes for Biological Sciences, CAS and Springer Nature Singapore Pte Ltd. 2018

Authors and Affiliations

  • Yuyanan Zhang
    • 1
    • 2
  • Hao Yan
    • 1
    • 2
  • Jinmin Liao
    • 1
    • 2
  • Hao Yu
    • 1
    • 2
    • 3
  • Sisi Jiang
    • 1
    • 2
  • Qi Liu
    • 1
  • Dai Zhang
    • 1
    • 2
    • 4
  • Weihua Yue
    • 1
    • 2
  1. 1.Institute of Mental HealthPeking University Sixth HospitalBeijingChina
  2. 2.Key Laboratory of Mental HealthMinistry of Health and National Clinical Research Center for Mental Disorders (Peking University)BeijingChina
  3. 3.Department of PsychiatryJining Medical UniversityJiningChina
  4. 4.Peking-Tsinghua Joint Center for Life Sciences and PKU-IDG/McGovern Institute for Brain ResearchPeking UniversityBeijingChina

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