Dendritic Cell Factor 1-Knockout Results in Visual Deficit Through the GABA System in Mouse Primary Visual Cortex
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The visual system plays an important role in our daily life. In this study, we found that loss of dendritic cell factor 1 (DCF1) in the primary visual cortex (V1) caused a sight deficit in mice and induced an abnormal increase in glutamic acid decarboxylase 67, an enzyme that catalyzes the decarboxylation of glutamate to gamma aminobutyric acid and CO2, particularly in layer 5. In vivo electrophysiological recordings confirmed a decrease in delta, theta, and beta oscillation power in DCF1-knockout mice. This study presents a previously unknown function of DCF1 in V1, suggests an unknown contact between DCF1 and GABA systems, and provides insight into the mechanism and treatment of visual deficits.
KeywordsDCF1 Sight GABA GAD67
This work was supported by the National Natural Science Foundation of China (81271253 and 81471162), the Science and Technology Commission of Shanghai Municipality, China (14JC1402400), and the Key Innovation Project of Shanghai Municipal Education Commission, China (14ZZ090).
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Conflict of interest
All authors claim that there are no conflicts of interest.