Radio Electric Asymmetric Conveyer Technology Modulates Neuroinflammation in a Mouse Model of Neurodegeneration

Neuroscience Bulletin volume 34, pages270–282(2018)Cite this article

Abstract

In this study, the effects of Radio Electric Asymmetric Conveyer (REAC), a non-invasive physical treatment, on neuroinflammatory responses in a mouse model of parkinsonism induced by intoxication with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), were investigated in vivo. We found that the REAC tissue optimization treatment specific for neuro-regenerative purposes (REAC TO-RGN-N) attenuated the inflammatory picture evoked by MPTP-induced nigro-striatal damage in mice, decreasing the levels of pro-inflammatory molecules and increasing anti-inflammatory mediators. Besides, there was a significant reduction of both astrocyte and microglial activation in MPTP-treated mice exposed to REAC TO-RGN-N. These results indicated that REAC TO-RGN-N treatment modulates the pro-inflammatory responses and reduces neuronal damage in MPTP-induced parkinsonism.

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Acknowledgements

We are grateful to Mr. Diego Mangiullo for technical assistance in animal cage assembly. This work was partially supported by a Fondazione Umberto Veronesi 2011 grant to RR, by a grant from the University of Bari (Fondi di Ateneo 2014), and by a grant from the University of Salento (Fondi di Ateneo 2014).

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Author notes

  1. Maria Antonietta Panaro, Alessandra Aloisi, and Giuseppe Nicolardi have contributed equally to this work.

Affiliations

  1. Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, Bari, Italy

    Maria Antonietta Panaro, Antonia Cianciulli & Rosa Calvello

  2. CNR Institute for Microelectronics and Microsystems, Via Monteroni (Campus Ecotekne), 73100, Lecce, Italy

    Alessandra Aloisi & Rosaria Rinaldi

  3. Department of Biological and Environmental Sciences and Technologies, Section of Human Anatomy, University of Salento, Lecce, Italy

    Giuseppe Nicolardi, Dario Domenico Lofrumento & Francesco De Nuccio

  4. Neuropathology Unit, Institute of Experimental Neurology, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milan, Italy

    Velia La Pesa

  5. Department of Mathematics and Physics, University of Salento, Via Arnesano, 73100, Lecce, Italy

    Rosaria Rinaldi

  6. CNR Institute of Nanoscience NEST, Piazza San Silvestro 12, 56127, Pisa, Italy

    Rosaria Rinaldi

  7. Department of Regenerative Medicine, Rinaldi Fontani Institute, Viale Belfiore 43, 50144, Florence, Italy

    Vania Fontani & Salvatore Rinaldi

  8. Research Department, Rinaldi Fontani Foundation, Viale Belfiore 43, 50144, Florence, Italy

    Vania Fontani & Salvatore Rinaldi

  9. IRF (Shanghai) Medical Sciences, 3000 Long Dong Avenue, Zhangjiang High-Tech Park, Shanghai, China

    Salvatore Rinaldi

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  1. Maria Antonietta Panaro
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  2. Alessandra Aloisi
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  4. Dario Domenico Lofrumento
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  11. Salvatore Rinaldi
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Correspondence to Dario Domenico Lofrumento.

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Conflict of interest

Salvatore Rinaldi and Vania Fontani are the inventors of REAC technology. They are also founders of the company that produces REAC technology.

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Panaro, M.A., Aloisi, A., Nicolardi, G. et al. Radio Electric Asymmetric Conveyer Technology Modulates Neuroinflammation in a Mouse Model of Neurodegeneration. Neurosci. Bull. 34, 270–282 (2018). https://doi.org/10.1007/s12264-017-0188-0

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Keywords

  • Parkinson’s disease
  • Neurodegeneration
  • Neuroinflammation
  • REAC TO-RGN-N treatment