In this study, the effects of Radio Electric Asymmetric Conveyer (REAC), a non-invasive physical treatment, on neuroinflammatory responses in a mouse model of parkinsonism induced by intoxication with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), were investigated in vivo. We found that the REAC tissue optimization treatment specific for neuro-regenerative purposes (REAC TO-RGN-N) attenuated the inflammatory picture evoked by MPTP-induced nigro-striatal damage in mice, decreasing the levels of pro-inflammatory molecules and increasing anti-inflammatory mediators. Besides, there was a significant reduction of both astrocyte and microglial activation in MPTP-treated mice exposed to REAC TO-RGN-N. These results indicated that REAC TO-RGN-N treatment modulates the pro-inflammatory responses and reduces neuronal damage in MPTP-induced parkinsonism.
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We are grateful to Mr. Diego Mangiullo for technical assistance in animal cage assembly. This work was partially supported by a Fondazione Umberto Veronesi 2011 grant to RR, by a grant from the University of Bari (Fondi di Ateneo 2014), and by a grant from the University of Salento (Fondi di Ateneo 2014).
Conflict of interest
Salvatore Rinaldi and Vania Fontani are the inventors of REAC technology. They are also founders of the company that produces REAC technology.
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Panaro, M.A., Aloisi, A., Nicolardi, G. et al. Radio Electric Asymmetric Conveyer Technology Modulates Neuroinflammation in a Mouse Model of Neurodegeneration. Neurosci. Bull. 34, 270–282 (2018). https://doi.org/10.1007/s12264-017-0188-0
- Parkinson’s disease
- REAC TO-RGN-N treatment