Neuroscience Bulletin

, Volume 33, Issue 5, pp 535–542 | Cite as

Can Biomarkers Help the Early Diagnosis of Parkinson’s Disease?

  • Weidong LeEmail author
  • Jie Dong
  • Song Li
  • Amos D. KorczynEmail author


Parkinson’s disease (PD) is a complex neurodegenerative disease with progressive loss of dopamine neurons. PD patients usually manifest a series of motor and non-motor symptoms. In order to provide better early diagnosis and subsequent disease-modifying therapies for PD patients, there is an urgent need to identify sensitive and specific biomarkers. Biomarkers can be divided into four categories: clinical, imaging, biochemical, and genetic. Ideal biomarkers not only improve our understanding of PD pathogenesis and progression, but also provide benefits for early risk evaluation and clinical diagnosis of PD. Although many efforts have been made and several biomarkers have been extensively investigated, few if any have been found useful for early diagnosis. Here, we summarize recent developments in the discovered biomarkers of PD and discuss their merits and limitations for the early diagnosis of PD.


Parkinson’s disease Biomarker Early diagnosis Molecular imaging Biochemical markers 



This review was supported by grants from the National Natural Science Foundation of China (81430021 and 81370470), the Program for Liaoning Provincial Innovative Research Team in Universities (LT2015009), the Liaoning Provincial Science and Technology Project (2015225008), and a Research Project of Dalian Science and Technology (2014E14SF175) of Liaoning Province, China.


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Copyright information

© Shanghai Institutes for Biological Sciences, CAS and Springer Nature Singapore Pte Ltd. 2017

Authors and Affiliations

  1. 1.Liaoning Provincial Center for Clinical Research on Neurological Diseases, The First Affiliated HospitalDalian Medical UniversityDalianChina
  2. 2.Liaoning Provincial Key Laboratory for Research on the Pathogenic Mechanisms of Neurological Diseases, The First Affiliated HospitalDalian Medical UniversityDalianChina
  3. 3.Collaborative Innovation Center for Brain Science, The First Affiliated HospitalDalian Medical UniversityDalianChina
  4. 4.Department of Neurology, Sackler School of MedicineTel Aviv UniversityRamat-AvivIsrael

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