Neuroscience Bulletin

, Volume 33, Issue 3, pp 281–291 | Cite as

Abnormal Effective Connectivity in the Brain is Involved in Auditory Verbal Hallucinations in Schizophrenia

  • Baojuan Li
  • Long-Biao Cui
  • Yi-Bin Xi
  • Karl J. Friston
  • Fan Guo
  • Hua-Ning Wang
  • Lin-Chuan Zhang
  • Yuan-Han Bai
  • Qing-Rong Tan
  • Hong Yin
  • Hongbing Lu
Original Article

Abstract

Information flow among auditory and language processing-related regions implicated in the pathophysiology of auditory verbal hallucinations (AVHs) in schizophrenia (SZ) remains unclear. In this study, we used stochastic dynamic causal modeling (sDCM) to quantify connections among the left dorsolateral prefrontal cortex (inner speech monitoring), auditory cortex (auditory processing), hippocampus (memory retrieval), thalamus (information filtering), and Broca’s area (language production) in 17 first-episode drug-naïve SZ patients with AVHs, 15 without AVHs, and 19 healthy controls using resting-state functional magnetic resonance imaging. Finally, we performed receiver operating characteristic (ROC) analysis and correlation analysis between image measures and symptoms. sDCM revealed an increased sensitivity of auditory cortex to its thalamic afferents and a decrease in hippocampal sensitivity to auditory inputs in SZ patients with AVHs. The area under the ROC curve showed the diagnostic value of these two connections to distinguish SZ patients with AVHs from those without AVHs. Furthermore, we found a positive correlation between the strength of the connectivity from Broca’s area to the auditory cortex and the severity of AVHs. These findings demonstrate, for the first time, augmented AVH-specific excitatory afferents from the thalamus to the auditory cortex in SZ patients, resulting in auditory perception without external auditory stimuli. Our results provide insights into the neural mechanisms underlying AVHs in SZ. This thalamic-auditory cortical-hippocampal dysconnectivity may also serve as a diagnostic biomarker of AVHs in SZ and a therapeutic target based on direct in vivo evidence.

Keywords

Effective connectivity Stochastic dynamic causal modeling Auditory verbal hallucinations Schizophrenia 

Supplementary material

12264_2017_101_MOESM1_ESM.pdf (21 kb)
Supplementary material 1 (PDF 20 kb)

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Copyright information

© Shanghai Institutes for Biological Sciences, CAS and Springer Science+Business Media Singapore 2017

Authors and Affiliations

  • Baojuan Li
    • 1
  • Long-Biao Cui
    • 2
  • Yi-Bin Xi
    • 2
  • Karl J. Friston
    • 3
  • Fan Guo
    • 2
  • Hua-Ning Wang
    • 4
  • Lin-Chuan Zhang
    • 1
  • Yuan-Han Bai
    • 4
  • Qing-Rong Tan
    • 4
  • Hong Yin
    • 2
  • Hongbing Lu
    • 1
  1. 1.School of Biomedical EngineeringFourth Military Medical UniversityXi’anChina
  2. 2.Department of Radiology, Xijing HospitalFourth Military Medical UniversityXi’anChina
  3. 3.Wellcome Trust Center for Neuroimaging, Institute of NeurologyUniversity College LondonLondonUK
  4. 4.Department of Psychiatry, Xijing HospitalFourth Military Medical UniversityXi’anChina

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