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Glial Activation, A Common Mechanism Underlying Spinal Synaptic Plasticity?

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References

  1. Liu XG, Zhou LJ. Long-term potentiation at spinal C-fiber synapses: a target for pathological pain. Curr Pharm Des 2015, 21: 895–905.

    Article  CAS  PubMed  Google Scholar 

  2. Liu XG, Sandkuhler J. Long-term potentiation of C-fiber-evoked potentials in the rat spinal dorsal horn is prevented by spinal N-methyl-d-aspartic acid receptor blockage. Neurosci Lett 1995, 191: 43–46.

    Article  CAS  PubMed  Google Scholar 

  3. Gong QJ, Li YY, Xin WJ, Zang Y, Ren WJ, Wei XH, et al. ATP induces long-term potentiation of C-fiber-evoked field potentials in spinal dorsal horn: The roles of P2X(4) receptors and p38 MAPK in microglia. Glia 2009, 57: 583–591.

    Article  PubMed  Google Scholar 

  4. Zhou LJ, Yang T, Wei XA, Liu Y, Xin WJ, Chen YA, et al. Brain-derived neurotrophic factor contributes to spinal long-term potentiation and mechanical hypersensitivity by activation of spinal microglia in rat. Brain Behav Immun 2011, 25: 322–334.

    Article  CAS  PubMed  Google Scholar 

  5. Drdla R, Gassner M, Gingl E, Sandkuhler J. Induction of synaptic long-term potentiation after opioid withdrawal. Science 2009, 325: 207–210.

    Article  CAS  PubMed  Google Scholar 

  6. Kronschläger MT, Drdla-Schutting R, Gassner M, Honsek SD, Teuchmann HL, Sandkühler J. Gliogenic LTP spreads widely in nociceptive pathways. Science 2016, 354: 1144–1148. doi: 10.1126/science.aah5715.

    Article  PubMed  Google Scholar 

  7. Zhou LJ, Ren WJ, Zhong Y, Yang T, Wei XH, Xin WJ, et al. Limited BDNF contributes to the failure of injury to skin afferents to produce a neuropathic pain condition. Pain 2010, 148: 148–157.

    Article  CAS  PubMed  Google Scholar 

  8. Gong QJ, Li YY, Xin WJ, Wei XH, Cui Y, Wang J, et al. Differential effects of adenosine A1 receptor on pain-related behavior in normal and nerve-injured rats. Brain Res 2010, 1361: 23–30.

    Article  CAS  PubMed  Google Scholar 

  9. Ying B, Lu N, Zhang YQ, Zhao ZQ. Involvement of spinal glia in tetanically sciatic stimulation-induced bilateral mechanical allodynia in rats. Biochem Biophys Res Commun 2006, 340: 1264–1272.

    Article  CAS  PubMed  Google Scholar 

  10. Chu YX, Zhang Y, Zhang YQ, Zhao ZQ. Involvement of microglial P2X7 receptors and downstream signaling pathways in long-term potentiation of spinal nociceptive responses. Brain Behav Immun 2010, 24: 1176–1189.

    Article  CAS  PubMed  Google Scholar 

  11. Liu YL, Zhou LJ, Hu NW, Xu JT, Wu CY, Zhang T, et al. Tumor necrosis factor-alpha induces long-term potentiation of C-fiber evoked field potentials in spinal dorsal horn in rats with nerve injury: the role of NF-kappa B, JNK and p38 MAPK. Neuropharmacology 2007, 52: 708–715.

    Article  CAS  PubMed  Google Scholar 

  12. Zhong Y, Zhou LJ, Ren WJ, Xin WJ, Li YY, Zhang T, et al. Interleukin-1beta induces long-term potentiation of C-fiber evoked field potentials in spinal dorsal horn in rats with neuropathic pain. Open Pain J 2009, 2: 18–23.

    Article  CAS  Google Scholar 

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Correspondence to Xian-Guo Liu.

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Zhou, LJ., Liu, XG. Glial Activation, A Common Mechanism Underlying Spinal Synaptic Plasticity?. Neurosci. Bull. 33, 121–123 (2017). https://doi.org/10.1007/s12264-016-0091-0

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