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Neuroscience Bulletin

, Volume 30, Issue 2, pp 243–252 | Cite as

Neuronal failure in Alzheimer’s disease: a view through the oxidative stress looking-glass

  • David J. Bonda
  • Xinglong Wang
  • Hyoung-Gon Lee
  • Mark A. Smith
  • George Perry
  • Xiongwei ZhuEmail author
Review

Abstract

Considerable debate and controversy surround the cause(s) of Alzheimer’s disease (AD). To date, several theories have gained notoriety, however none is universally accepted. In this review, we provide evidence for the oxidative stress-induced AD cascade that posits aged mitochondria as the critical origin of neurodegeneration in AD.

Keywords

Alzheimer’s disease amyloid-beta free radicals mitochondria mitochondrial dynamics oxidative stress 

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Copyright information

© Shanghai Institutes for Biological Sciences, CAS and Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • David J. Bonda
    • 1
  • Xinglong Wang
    • 1
  • Hyoung-Gon Lee
    • 1
  • Mark A. Smith
    • 1
  • George Perry
    • 1
    • 2
  • Xiongwei Zhu
    • 1
    Email author
  1. 1.Department of PathologyCase Western Reserve UniversityClevelandUSA
  2. 2.UTSA Neurosciences Institute and Department of BiologyUniversity of Texas at San AntonioSan AntonioUSA

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