Neuroscience Bulletin

, Volume 28, Issue 5, pp 658–666 | Cite as

Neuronal autophagy in cerebral ischemia

  • Feng Xu
  • Jin-Hua Gu
  • Zheng-Hong Qin


Autophagy has evolved as a conserved process for the bulk degradation and recycling of cytosolic components, such as long-lived proteins and organelles. In neurons, autophagy is important for homeostasis and protein quality control and is maintained at relatively low levels under normal conditions, while it is upregulated in response to pathophysiological conditions, such as cerebral ischemic injury. However, the role of autophagy is more complex. It depends on age or brain maturity, region, severity of insult, and the stage of ischemia. Whether autophagy plays a beneficial or a detrimental role in cerebral ischemia depends on various pathological conditions. In this review, we elucidate the role of neuronal autophagy in cerebral ischemia.


autophagy cerebral ischemia neuron apoptosis necrosis 


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Copyright information

© Shanghai Institutes for Biological Sciences, CAS and Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  1. 1.Department of Neurosurgery, Huashan HospitalFudan UniversityShanghaiChina
  2. 2.Department of PharmacologyNantong University School of MedicineNantongChina
  3. 3.Department of Pharmacology and Laboratory of Aging and Nervous DiseasesSoochow University School of Pharmaceutical ScienceSuzhouChina

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