Abstract
Pain perception and its genesis in the human brain have been reviewed recently. In the current article, the reports on pain modulation in the human brain were reviewed from higher cortical regulation, i.e. top-down effect, particularly studied in psychological determinants. Pain modulation can be examined by gene therapy, physical modulation, pharmacological modulation, psychological modulation, and pathophysiological modulation. In psychological modulation, this article examined (a) willed determination, (b) distraction, (c) placebo, (d) hypnosis, (e) meditation, (f) qi-gong, (g) belief, and (h) emotions, respectively, in the brain function for pain modulation. In each, the operational definition, cortical processing, neuroimaging, and pain modulation were systematically deliberated. However, not all studies had featured the brain modulation processing but rather demonstrated potential effects on human pain. In our own studies on the emotional modulation on human pain, we observed that emotions could be induced from music melodies or pictures perception for reduction of tonic human pain, mainly in potentiation of the posterior alpha EEG fields, likely resulted from underneath activities of precuneous in regulation of consciousness, including pain perception. To sum, higher brain functions become the leading edge research in all sciences. How to solve the information bit of thinking and feeling in the brain can be the greatest challenge of human intelligence. Application of higher cortical modulation of human pain and suffering can lead to the progress of social humanity and civilization.
摘要
最近的研究报道了痛知觉和它的人脑起源。 本文综述了人类疼痛的高等皮层调节(下行调节), 尤其强调了心理要素。 疼痛调节可包括基因治疗、 生理、 药理、 心理和病理生理调节。 在心理学调节中, 本文从脑功能变化对疼痛的调节分别阐述了以下方面: (a)意志, (b)分心, (c)安慰剂, (d)催眠, (e)沉思, (f)气功, (g)信念, (h)情绪。 本文系统详实地描述了操作定义、 皮层处理、 脑成像和疼痛调节。 尽管并非所有研究均集中于疼痛调节的进展, 但它们证明了人类疼痛调节的潜在方法。 在对情绪调节疼痛的研究中, 音乐旋律和图片认知对人持续性疼痛的调节作用已逐渐被发现。 脑电量定位研究显示其机理主要为α波的增加, 这可能与侧顶叶皮层对意识的调节和疼痛感知有关。 总之, 高等脑功能正成为最顶端的科学研究领域。 如何 解开思维及情绪在脑中的编码是人类崇高的智慧挑战。 应用高等脑功能解脱人类的痛苦是人道的文明进展。
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References
Watkins LR, Mayer DJ. Organization of endogenous opiate and nonopiate pain control systems. Science 1982, 216(4551): 1185–1192.
Fields H. Pain modulation: opiates and chronic pain. NIDA Res Monogr 1989, 95: 92–101.
Chen AC. Human brain measures of clinical pain: a review. I. Topographic mappings. Pain 1993, 54(2): 115–132.
Chen AC. Human brain measures of clinical pain: a review. II. Tomographic imagings. Pain 1993, 54(2): 133–144.
Chen AC. Pain perception and its genesis in the human brain. Sheng Li Xue Bao 2008, 60(5): 677–685.
Apkarian AV, Bushnell MC, Treede RD, Zubieta JK. Human brain mechanisms of pain perception and regulation in health and disease. Eur J Pain 2005, 9(4):463–484.
Moisset X, Bouhassira D. Brain imaging of neuropathic pain. Neuroimage 2007, 37Suppl 1: S80–88.
Mohr C, Binkofski F, Erdmann C, Büchel C, Helmchen C. The anterior cingulate cortex contains distinct areas dissociating external from self-administered painful stimulation: a parametric fMRI study. Pain 2005, 114(3): 347–357.
Helmchen C, Mohr C, Erdmann C, Binkofski F, Büchel C. Neural activity related to self-versus externally generated painful stimuli reveals distinct differences in the lateral pain system in a parametric fMRI study. Hum Brain Mapp 2006, 27(9): 755–765.
Mohr C, Leyendecker S, Helmchen C. Dissociable neural activity to self- vs externally administered thermal hyperalgesia: a parametric fMRI study. Eur J Neurosci 2008, 27(3): 739–749.
Ohara S, Crone NE, Weiss N, Lenz FA. Attention to a painful cutaneous laser stimulus modulates electrocorticographic eventrelated desynchronization in humans. Clin Neurophysiol 2004, 115(7): 1641–1652.
Beydoun A, Morrow TJ, Shen JF, Casey KL. Variability of laser-evoked potentials: attention, arousal and lateralized differences. Electroencephalogr Clin Neurophysiol 1993, 88(3): 173–181.
Del Percio C, Le Pera D, Arendt-Nielsen L, Babiloni C, Brancucci A, Chen AC, et al. Distraction affects frontal alpha rhythms related to expectancy of pain: an EEG study. Neuroimage 2006, 31(3): 1268–1277.
Wiech K, Ploner M, Tracey I. Neurocognitive aspects of pain perception. Trends Cogn Sci 2008, 12(8): 306–313.
Kupers R, Faymonville ME, Laureys S. The cognitive modulation of pain: hypnosis- and placebo-induced analgesia. Prog Brain Res 2005, 150: 251–269.
Bingel U, Lorenz J, Schoell E, Weiller C, Büchel C. Mechanisms of placebo analgesia: rACC recruitment of a subcortical antinociceptive network. Pain 2006, 120(1–2): 8–15.
Craggs JG, Price DD, Verne GN, Perlstein WM, Robinson MM. Functional brain interactions that serve cognitive-affective processing during pain and placebo analgesia. Neuroimage 2007, 38(4): 720–729.
Kong J, Kaptchuk TJ, Polich G, Kirsch I, Gollub RL. Placebo analgesia: findings from brain imaging studies and emerging hypotheses. Rev Neurosci 2007, 18(3–4): 173–190.
Nemoto H, Nemoto Y, Toda H, Mikuni M, Fukuyama H. Placebo analgesia: a PET study. Exp Brain Res 2007, 179(4): 655–664.
Kong J, Gollub RL, Rosman IS, Webb JM, Vangel MG, Kirsch I, et al. Brain activity associated with expectancy-enhanced placebo analgesia as measured by functional magnetic resonance imaging. J Neurosci 2006, 26(2): 381–388.
Lidstone SC, Stoessl AJ. Understanding the placebo effect: contributions from neuroimaging. Mol Imaging Biol 2007, 9(4): 176–185.
Faymonville ME, Boly M, Laureys S. Functional neuroanatomy of the hypnotic state. J Physiol Paris 2006, 99(4–6): 463–469.
Faymonville ME, Roediger L, Del Fiore G, Delgueldre C, Phillips C, Lamy M, et al. Increased cerebral functional connectivity underlying the antinociceptive effects of hypnosis. Brain Res Cogn Brain Res 2003, 17(2): 255–262.
Rainville P, Hofbauer RK, Paus T, Duncan GH, Bushnell MC, Price DD. Cerebral mechanisms of hypnotic induction and suggestion. J Cogn Neurosci 1999, 11(1): 110–125.
Feldman JB. Expanding hypnotic pain management to the affective dimension o of pain. Am J Clin Hypn 2009, 51(3): 235–254.
Horton JE, Crawford HJ, Harrington G, Downs JH 3rd. Increased anterior corpus callosum size associated positively with hypnotizability and the ability to control pain. Brain 2004, 127(Pt 8): 1741–1747.
Derbyshire SW, Whalley MG, Stenger VA, Oakley DA. Cerebral activation during hypnotically induced and imagined pain. Neuroimage 2004, 23(1): 392–401.
Derbyshire SW, Whalley MG, Oakley DA. Fibromyalgia pain and its modulation by hypnotic and non-hypnotic suggestion: an fMRI analysis. Eur J Pain 2009, 13(5): 542–550.
Lou HC, Nowak M, Kjaer TW. The mental self. Prog Brain Res 2005, 150: 197–204.
Orme-Johnson DW, Schneider RH, Son YD, Nidich S, Cho ZH. Neuroimaging of meditation’s effect on brain reactivity to pain. Neuroreport 2006, 17(12): 1359–1363.
Kakigi R, Nakata H, Inui K, Hiroe N, Nagata O, Honda M, et al. Intracerebral pain processing in a Yoga Master who claims not to feel pain during meditation. Eur J Pain 2005, 9(5): 581–589.
Cahn BR, Polich J. Meditation states and traits: EEG, ERP, and neuroimaging studies. Psychol Bull 2006, 132(2): 180–211.
Hölzel BK, Ott U, Hempel H, Hackl A, Wolf K, Stark R, et al. Differential engagement of anterior cingulate and adjacent medial frontal cortex in adept meditators and non-meditators. Neurosci Lett 2007, 421(1): 16–21.
Lutz A, Brefczynski-Lewis J, Johnstone T, Davidson RJ. Regulation of the neural circuitry of emotion by compassion meditation: effects of meditative expertise. PLoS One 2008, 3(3): e1897.
Yu WL, Li XQ, Tang WJ, Li Y, Weng XC, Chen YZ. fMRI study of pain reaction in the brain under state of “Qigong”. Am J Chin Med 2007, 35(6): 937–945.
Schjødt U, Stødkilde-Jørgensen H, Geertz AW, Roepstorff A. Rewarding prayers. Neurosci Lett 2008, 443(3): 165–168.
Schjoedt U, Stødkilde-Jørgensen H, Geertz AW, Roepstorff A. Highly religious participants recruit areas of social cognition in personal prayer. Soc Cogn Affect Neurosci 2009, 4(2): 199–207.
Kapogiannis D, Barbey AK, Su M, Zamboni G, Krueger F, Grafman J. Cognitive and neural foundations of religious belief. Proc Natl Acad Sci U S A 2009, 106(12): 4876–4881.
Han S, Mao L, Gu X, Zhu Y, Ge J, Ma Y. Neural consequences of religious belief on self-referential processing. Soc Neurosci 2008, 3(1): 1–15.
Han S, Gu X, Mao L, Ge J, Wang G, Ma Y.Neural substrates of self-referential processing in Chinese Buddhists. Soc Cogn Affect Neurosci 2009, in press.
Brown CA, Seymour B, El-Deredy W, Jones AK. Confidence in beliefs about pain predicts expectancy effects on pain perception and anticipatory processing in right anterior insula. Pain 2008, 139(2): 324–332.
Wiech K, Farias M, Kahane G, Shackel N, Tiede W, Tracey I. An fMRI study measuring analgesia enhanced by religion as a belief system. Pain 2008, 139(2): 467–476.
Rainville P. Brain mechanisms of pain affect and pain modulation. Curr Opin Neurobiol 2002, 12(2): 195–204.
Price DD, Verne GN, Schwartz JM. Plasticity in brain processing and modulation of pain. Prog Brain Res 2006, 157: 333–352.
Tracey I, Mantyh PW. The cerebral signature for pain perception and its modulation. Neuron 2007, 55(3): 377–391.
Zhao H, Chen AC. Both happy and sad melodies modulate tonic human heat pain. Pain 2009, 10(9): 953–960.
Cavanna AE. The precuneus and consciousness. CNS Spectr 2007, 12(7): 545–552.
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Chen, A.C. Higher cortical modulation of pain perception in the human brain: Psychological determinant. Neurosci. Bull. 25, 267–276 (2009). https://doi.org/10.1007/s12264-009-0918-z
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DOI: https://doi.org/10.1007/s12264-009-0918-z