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Roles of NF-κB in central nervous system damage and repair

NF-κB 在中枢神经系统损伤和修复中的作用

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Abstract

NF-κB family is a kind of nuclear factors in B lymphocyte that can bind to the immunoglobulin κ-chain enhancer and enhance transcriptional activity. NF-κB/Rel proteins, as a dimeric transcription factor, control the expression of genes that regulate a broad range of biological processes through canonical and non-canonical pathways. In the central nervous system, NF-κB controls inflammatory reactions and the apoptotic cell death following nerve injury. It also contributes to the infarction and cell death in stroke models and patients. However, NF-κB is essential for neurosurvival as well. NF-κB activation is a part of recovery process that may protect neurons against oxidative-stresses or brain ischemia-induced apoptosis and neurodegeneration. Inhibition of NF-κB may reduce its neuroprotection activity. Hence the dual opposite effects of NF-κB on cells. The ultimate survival or death of neurons depends on which, where and when the NF-κB factors are activated.

摘要

细胞核因子-κB(nuclear factor kappa B, NF-κB) 家族是 B 淋巴细胞核因子, 它能够与免疫球蛋白 κ 链增强子结合并增加各种基因的表达活性。 NF-κB 通过典型和非典型途径的激活来控制和调节各种生理病理过程。 在中枢神经系统, NF-κB 调控炎症反应、 神经损伤后的神经细胞凋亡等, 它可以促进中风等缺血性脑损伤的脑梗死面积和神经元死亡, 同时又对神经元的存活有重要影响。 NF-κB 激活是神经康复的重要组成部分, 它能够保护神经元免于由氧化应激和脑缺血诱导的神经元凋亡和变性, 阻滞 NF-κB 活性将影响它的神经保护机制。 NF-κB 这种对神经元存活和死亡的双重效应取决于 NF-κB 激活的亚单位类型、激活所处的损伤位置以及损伤后修复的时程。

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Correspondence to Xi-Ping Chen  (陈溪萍).

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Yang, L., Tao, LY. & Chen, XP. Roles of NF-κB in central nervous system damage and repair. Neurosci. Bull. 23, 307–313 (2007). https://doi.org/10.1007/s12264-007-0046-6

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