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Survival dependant upon site of colorectal cancer and timing of liver metastasis after hepatectomy

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Abstract

Factors affecting overall survival (OS) after hepatectomy for colorectal cancer liver metastases (CRCLM) are unknown. This study aimed to investigate the effect of the location of the primary tumor and the timing of liver metastases on OS in patients with CRCLM who underwent hepatectomy. Patients with CRCLM who underwent hepatectomy between August 2005 and December 2019 were retrospectively enrolled in this study, at our institution. In total, 87 patients with CRCLM who underwent hepatectomy were included in this study. The primary tumor was located on the right and left sides in 27 (31%) and 60 (69%) patients, respectively. A total of 53 (61%) and 34 (39%) patients had synchronous and metachronous liver metastases, respectively. The median OS period for all patients was 31 (interquartile range [IQR], 21.3–40.7) months. The median OS periods in the right and left-sided groups were 26 (IQR, 11.7–40.3) and 32 (IQR, 23.1–40.8) months, respectively. There was no significant difference between the two groups. The median OS periods for the synchronous and metachronous groups were 26 (IQR, 21.5–30.5) and 76 (IQR, 28.2–123.8; P = 0.001) months, respectively. Cox proportional hazards model analysis showed that synchronous liver metastases were associated with poorer OS. The hazard ratio was 2.405 (95% confidence interval, 1.364–4.240; P = 0.002) Primary tumor location has no effect on OS after hepatectomy in patients with CRCLM. Synchronous liver metastases are associated with poorer OS after hepatectomy in patients with CRCLM.

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Acknowledgements

We would like to thank Editage (www.editage.co.kr) for English language editing.

Funding

No funding was received for conducting this study.

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Authors and Affiliations

  1. Department of Surgery, College of Medicine, Chungbuk National University, Cheongju, Korea

    KangHe Xu, Dong Hee Ryu, Jae-Woon Choi & Hanlim Choi

  2. Department of Surgery, Chungbuk National University Hospital, Cheongju, Korea

    Dong Hee Ryu, Jae-Woon Choi & Hanlim Choi

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Contributions

Conceptualization: Dong Hee Ryu, KangHe Xu.

Collected and assembled the data of the study: KangHe Xu, Hanlim Choi.

Data analysis: Dong Hee Ryu, Jae-Woon Choi, KangHe Xu.

Writing—original draft preparation: KangHe Xu.

Writing—review and editing: Dong Hee Ryu, KangHe Xu, Jae-Woon Choi, Hanlim Choi.

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Correspondence to Dong Hee Ryu.

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Ethics Approval

This study was approved by the Institutional Review Board of Chungbuk National University Hospital (IRB No.: 2022–02-020).

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Xu, K., Ryu, D.H., Choi, JW. et al. Survival dependant upon site of colorectal cancer and timing of liver metastasis after hepatectomy. Indian J Surg 86, 82–88 (2024). https://doi.org/10.1007/s12262-023-03790-4

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  • DOI: https://doi.org/10.1007/s12262-023-03790-4

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