Vitamin C may have positive effects on wound healing and improve quality of life and the recovery process. A systematic review was done to study the effects of vitamin C on the healing of wounds and thereby hasten rehabilitation. Randomized controlled trials (RCTs) and controlled clinical trials on the effects of vitamin C were searched for using PubMed, Google Scholar, Science Direct, and Cochrane Library. Data was collected, analyzed, and assessed for risks of bias using Cochrane review protocols and tools. A total of 24 trials were procured, but after excluding 21 that did not meet the criteria, only three trials could be analyzed. Overall, addition of vitamin C was noted to have 3.94 times likelihood of acquiring quicker recovery process as compared to placebo (OR 3.99, 95% CI 2.06 to 7.73), but there was no difference in pain (p > 0.05). Overall quality of evidence was good, with low risk of bias. Evidence shows that vitamin C promotes wound healing by hastening recovery and attaining high leucocyte ascorbic acid levels. It is recommended to use vitamin C for wound healing while waiting for more RCTs to strengthen this evidence.
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Wang PH, Huang BS, Horng HC, Yeh CC, Chen YJ (2018) Wound healing. J Chin Med Assoc 81(2):94–101. https://doi.org/10.1016/j.jcma.2017.11.002
Ekegren CL, Edwards ER, de Steiger R, Gabbe BJ (2018) Incidence, costs and predictors of non-union, delayed union and mal-union following long bone fracture. Int J Environ Res Public Health 15(12):E2845. https://doi.org/10.3390/ijerph15122845
Mohammed BM, Fisher BJ, Kraskauskas D, Ward S, Wayne JS, Brophy DF et al (2016) Vitamin C promotes wound healing through novel pleiotropic mechanisms. Int Wound J 13:572–584. https://doi.org/10.1111/iwj.12484
Duarte TL, Cooke MS, Jones GD (2009) Gene expression profiling reveals new protective roles for vitamin C in human skin cells. Free Radic Biol Med 46:78–87. https://doi.org/10.1016/j.freeradbiomed.2008.09.028
Parsons KK, Maeda N, Yamauchi M, Banes AJ, Koller BH (2006) Ascorbic acid-independent synthesis of collagen in mice. Am J Physiol Endocrinol Metab 290:E1131–E1139. https://doi.org/10.1152/ajpendo.00339.2005
Ross R, Benditt EP (1962) Wound healing and collagen formation. II. Fine structure in experimental scurvy. J Cell Biol 12:533–551. https://doi.org/10.1083/jcb.12.3.533
Blass SC, Goost H, Tolba RH, Stoffel-Wagner B, Kabir K, Burger C et al (2012) Time to wound closure in trauma patients with disorders in wound healing is shortened by supplements containing antioxidant micronutrients and glutamine: a PRCT. Clin Nutr 31:469–475. https://doi.org/10.1016/j.clnu.2012.01.002
Aghajanian P, Hall S, Wongworawat MD, Mohan S (2015) The roles and mechanisms of actions of vitamin C in bone: new developments. J Bone Miner Res 30(11):1945–1955. https://doi.org/10.1002/jbmr.2709
Motoji H, To M, Hidaka K, Matsuo M (2020) Vitamin Cand eggshell membrane facilitate orthodontic tooth movement and induce histological changes in the periodontal tissue. J Oral Biosci S1349-0079(20):30006–30002. https://doi.org/10.1016/j.job.2020.01.006
Ubbink DT, Santema TB, Stoekenbroek RM (2014) Systemic wound care: a meta-review of cochrane systematic reviews. Surg Technol Int 24:99–111
Abrahmsohn GM, Halberstein RA, Fregeolle S (1993) Vitamin C and dental healing: testing and placebo effect. Gen Dent 41(6):523–527
Taylor TV, Rimmer S, Day B, Butcher J, Dymock IW (1974) Ascorbic acid supplementation in the treatment of pressure-sores. Lancet 2(7880):544–546. https://doi.org/10.1016/s0140-6736(74)91874-1
Zollinger PE, Tuinebreijer WE, Kreis RW, Breederveld RS (1999) Effect of vitamin C on frequency of reflex sympathetic dystrophy in wrist fractures: a randomised trial. Lancet 354(9195):2025–2028. https://doi.org/10.1016/S0140-6736(99)03059-7
Burr RG, Rajan KT (1972) Leucocyte ascorbic acid and pressure sores in paraplegia. Br J Nutr 28(2):275–281
Woolfe SN, Kenney EB, Hume WR, Carranza FA (1984) Relationship of ascorbic acid levels of blood and gingival tissue with response to periodontal therapy. J Clin Periodontol 11(3):159–165. https://doi.org/10.1111/j.1600-051x.1984.tb01319.x
Ekrol I, Duckworth AD, Ralston SH, Court-Brown CM, McQueen MM (2014) The influence of vitamin C on the outcome of distal radial fractures: a double-blind, randomized controlled trial. J Bone Joint Surg 96(17):1451–1459. https://doi.org/10.2106/JBJS.M.00268
Lange-de Klerk ES (2000) Lower incidence of posttraumatic dystrophy in wrist fractures after prophylactic supplementation of vitamin C. Ned Tijdschr Geneeskd 144(42):2035–2036
ter Riet G, Kessels AG, Knipschild PG (1995) Randomized clinical trial of ascorbic acid in the treatment of pressure ulcers. J Clin Epidemiol 48(12):1453–1460. https://doi.org/10.1016/0895-4356(95)00053-4
Savitsky B, Radomislensky I, Goldman S, Gitelson N, Frid Z, Peleg K (2020) Returning to work following an injury: practical usage of a predictive model based on a nationwide study. J Community Health 45(1):183–193. https://doi.org/10.1007/s10900-019-00730-w
Rahim K, Saleha S, Zhu X, Huo L, Basit A, Franco OL (2017) Bacterial contribution in chronicity of wounds. Microb Ecol 73(3):710–721. https://doi.org/10.1007/s00248-016-0867-9
Powers JG, Higham C, Broussard K, Phillips TJ (2016) Wound healing and treating wounds: chronic wound care and management. J Am Acad Dermatol 74(4):607–625. https://doi.org/10.1016/j.jaad.2015.08.070
Chaitanya NC, Badam R, Siva Prasad Reddy G et al (2019) Analgesic effect of intravenous ascorbic acid versus acelcofenac post-transalveolar extraction:a case-control study. J Popul Ther Clin Pharmacol 26(2):e43–e52
Laflı Tunay D, Türkeün Ilgınel M, Ünlügenç H, Tunay M, Karacaer F, Biricik E (2020) Comparison of the effects of preoperative melatonin or vitamin C administration on postoperative analgesia. Bosn J Basic Med Sci 20(1):117–124
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Thevi, T., Abas, A.L. & Rajan, M. The Effects of Vitamin C on Wound Healing—Systematic Review. Indian J Surg (2023). https://doi.org/10.1007/s12262-023-03750-y