Abstract
Juvenile papillomatosis (JP) of breast is a rare benign proliferative disease of the female breast which can be seen in women younger than 30 years of age. They usually present with a mobile lump in the breast, which can be easily mistaken clinically for a fibroadenoma. A 16-year-old girl presented to our outpatient with history of nipple discharge from the left breast which she noticed 1.5 years back. The discharge was occasionally blood stained. Physical examination revealed multiple diffuse mobile lumps in both the breasts. Imaging and core needle biopsy were suggestive of juvenile papillomatosis. Hence, USG-guided wire localization and excision of the affected ductal system was planned. Gross and microscopic sections were also confirmative of juvenile papillomatosis. Our patient was an unusual case of juvenile papillomatosis presenting with nipple discharge and bilateral multiple breast lumps with no family history. An ideal treatment for juvenile papillomatosis should be wide local excision with careful watch (Rosen PP et al., Am J Surg Pathol 4(1):3–12, 1980). Due to extensive disease in both breasts, a complete excision would have led to mastectomy. In the absence of consent for mastectomy, the present patient was treated by wide local excision of the involved duct only without any adjuvant treatment. She was counselled and warned for regular close follow-up. It was emphasised that she should undergo a risk-reducing bilateral mastectomy once she has had completed her family.
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References
Rosen PP, Cantrell B, Mullen DL, DePalo A (1980) Juvenile papillomatosis (Swiss cheese disease) of the breast. Am J Surg Pathol 4(1):3–12
Rosen PP, Lyngholm B, Kinne DW, Beattie EJ Jr (1982) Juvenile papillomatosis of the breast and family history of breast carcinoma. Cancer 49(12):2591–2595. https://doi.org/10.1002/1097-0142(19820615)49:12%3c2591::aid-cncr2820491230%3e3.0.co;2-o
Rosen PP, Holmes G, Lesser ML, Kinne DW, Beattie EJ (1985) Juvenile papillomatosis and breast carcinoma. Cancer 55(6):1345–1352. https://doi.org/10.1002/1097-0142(19850315)55:6%3c1345::aid-cncr2820550631%3e3.0.co;2-b
Wang T, Li YQ, Liu H, Fu XL, Tang SC (2014) Bifocal juvenile papillomatosis as a marker of breast cancer: a case report and review of the literature. Oncol Lett 8(6):2587–2590. https://doi.org/10.3892/ol.2014.2600
Bazzocchi F, Santini D, Martinelli G, Piccaluga A, Taffurelli M, Grassigli A, Marrano D (1986) Juvenile papillomatosis (epitheliosis) of the breast A clinical and pathologic study of 13 cases. Am J Clin Pathol 86(6):745–8. https://doi.org/10.1093/ajcp/86.6.745
Vandeweerd V, Keupers M, Hoste G, Langenaeken T, Neven P (2019) Juvenile papillomatosis: a case report. Eur J Breast Health 15(2):130–134. https://doi.org/10.5152/ejbh.2019.4362
Lad S, Seely J, Elmaadawi M, Peddle S, Perkins G, Robertson S, Arnaout A (2014) Juvenile papillomatosis: a case report and literature review. Clin Breast Cancer 14(5):e103–e105. https://doi.org/10.1016/j.clbc.2014.03.003
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Balaji Subramaniam, Mala Mathur Sharma, Janaki P. Dharmarajan and Jyotsna Yesodharan: concepts, design, definition of intellectual content, literature search, clinical studies, experimental studies, data acquisition, data analysis, statistical analysis, manuscript preparation, manuscript editing, manuscript review, guarantor.
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Key Messages
The diagnosis of juvenile papillomatosis of breast can be easily missed as it is not a commonly encountered disease. A keen eye of suspicion is important in diagnosing and treating this silent disease with malignant potential.
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Subramaniam, B., Sharma, M.M., Dharmarajan, J.P. et al. Bilateral Juvenile Papillomatosis of Breast—a Rare Case Report. Indian J Surg 85, 1467–1470 (2023). https://doi.org/10.1007/s12262-023-03736-w
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DOI: https://doi.org/10.1007/s12262-023-03736-w