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Oxidative Stress Enzyme NOX1 Is a New and Important Biomarker for Childhood Appendicitis?

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Abstract

Delayed appendicitis diagnosis may result in perforation and an increased risk of mortality. This study aimed to assess the diagnostic value of ischemia-modified albumin, nicotinamide adenine dinucleotide phosphate oxidase 1, 2, and 4 levels in the diagnosis of non-complicated and complicated appendicitis. The study included 60 pediatric patients who presented to our clinic with a complaint of abdominal pain and underwent surgery with a diagnosis of appendicitis between November 2020 and December 2021 and also included 30 controls. Cases were divided into three groups: (i) non-complicated appendicitis (n = 30), (ii) complicated appendicitis (n = 30), and (iii) control (n = 30). The nicotinamide adenine dinucleotide phosphate oxidase 1 and 4 and ischemia-modified albumin levels were higher in non-complicated and complicated appendicitis compared to the control (p < 0.001). In addition, considering the odds ratio values, the most effective biomarkers in the diagnosis were nicotinamide adenine dinucleotide phosphate oxidase 1 and 2, and procalcitonin, while the most effective biomarkers in the prognosis were nicotinamide adenine dinucleotide phosphate oxidase 1 and 2, and neotrophil/lymphocyte ratios. The data suggested that since the most successful biomarker nicotinamide adenine dinucleotide phosphate oxidase 1, with a value of 0.98- area under the curve, is the most successful biomarker in both diagnosis and prognosis of the disease, it can be used as an important biomarker in childhood appendicitis.

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Funding

This work was supported by the Research Fund of Van Yuzuncu Yil University, project number: TSA-2021-9386.

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Authors and Affiliations

  1. Department of Pediatric Surgery, Medical Faculty, Lokman Hekim University, Ankara, Turkey

    Veli Avci

  2. Department of Pediatric Surgery, Medical Faculty, Van Yuzuncu Yil University, Van, Turkey

    Kemal Ayengin & Lokman Soysal

  3. Department of Biochemistry, Medical Faculty, Van Yuzuncu Yil University, Van, Turkey

    Zubeyir Huyut

  4. Department of Statistics, Medical Faculty, Erzincan Binali Yıldırım University, Erzincan, Turkey

    Mehmet Tahir Huyut

  5. Department of Pediatric Surgery, Medical Faculty, Mardin Artuklu University, Mardin, Turkey

    Salim Bilici

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  1. Veli Avci
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  2. Kemal Ayengin
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  3. Zubeyir Huyut
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  4. Mehmet Tahir Huyut
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  5. Lokman Soysal
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  6. Salim Bilici
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All of the authors declare that they have all participated in the design, execution, and analysis of the paper and that they have approved the final version.

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Correspondence to Veli Avci.

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Avci, V., Ayengin, K., Huyut, Z. et al. Oxidative Stress Enzyme NOX1 Is a New and Important Biomarker for Childhood Appendicitis?. Indian J Surg 85, 1139–1148 (2023). https://doi.org/10.1007/s12262-023-03695-2

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  • DOI: https://doi.org/10.1007/s12262-023-03695-2

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