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A Review of Surgical Perspectives of Breast Cancer Genetics and Risk-Reducing Surgery

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Abstract

Breast cancer is the most common cancer among women. A significant number of breast cancer patients have a family history of breast and/or ovarian cancer with associated high-risk genetic mutations. The culmination of translational research has helped in streaming guidelines and integration of genetic testing and interventions in the mainstream practice of oncology, especially in western countries. There are challenges of awareness, access, acceptability, and affordability for genetic testing and interventions in low to middle-income countries (LMIC). Surgeons play a vital role in the overall management of breast cancer and should take an initiative to familiarize and integrate into practice genetic counseling, genetic testing, and risk-reducing aspects of multidisciplinary breast cancer management. Risk-reducing surgery (RRS) is a complex and rapidly evolving field and surgeons dealing with breast cancer should be familiar with various dimensions of managing such patients. Several ethical, legal, and social issues are involved with genetic counseling and testing. A combined effort is needed to facilitate mainstreaming of genetic testing and risk-reducing surgery fields in LMIC.

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Authors and Affiliations

  1. Department of Surgical Oncology, Dr BR Ambedkar Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi, India

    S. V. S. Deo, Madiwalesh Chhebbi, Ashutosh Mishra & Jyoti Sharma

  2. Department of Medical Oncology, Dr BR Ambedkar Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi, India

    Ajay Gogia & Raja Pramanik

Authors
  1. S. V. S. Deo
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  2. Madiwalesh Chhebbi
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  3. Ashutosh Mishra
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  4. Jyoti Sharma
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  5. Ajay Gogia
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  6. Raja Pramanik
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Correspondence to S. V. S. Deo.

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Deo, S.V.S., Chhebbi, M., Mishra, A. et al. A Review of Surgical Perspectives of Breast Cancer Genetics and Risk-Reducing Surgery. Indian J Surg 84 (Suppl 3), 605–610 (2022). https://doi.org/10.1007/s12262-021-03119-z

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  • DOI: https://doi.org/10.1007/s12262-021-03119-z

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