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Expression of Thyroid Peroxidase Antibody, Thyroglobulin Antibody, and Thyrotropin Receptor Antibody in Breast Cancer and Their Associations with Clinical Characteristics of Breast Cancer

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Abstract

The relationship between chronic lymphocytic thyroiditis (CLT) and breast cancer was still unclear. We investigated the positivity of thyroid peroxidase antibody (TPO-ab), thyroglobulin antibody (TG-ab), and thyrotropin receptor antibody (TSHR-ab) in 362 patients with breast cancer, 360 patients with benign breast diseases, and 386 healthy controls. Further, we analyzed the associations between TPO-ab, TG-ab, TSHR-ab, and clinical characteristics in coastal residents with breast cancer according to molecular subtype. There were no significant differences in the levels of free triiodothyronine (FT3), free tetraiodothyronine (FT4), thyroid-stimulating hormone (TSH), and the positive rates of TG-ab and TSHR-ab among three groups. The positive rate of TPO-ab in patients with breast cancer was higher compared to patients with benign breast diseases and healthy controls (P=0.002). Axillary lymph node metastasis (ALNM) in breast cancer patients with positive TPO-ab was less frequent than breast cancer patients with negative TPO-ab (P=0.022). The percentage of TNM stage I–II patients with positive TPO-ab were higher than that in patients with negative TPO-ab (P= 0.029). TPO-ab was a predictor for low prevalence of ALNM in breast cancer patients with luminal A subtype (P=0.013) and luminal B subtype (P=0.024), but not for breast cancer patients with HER2 over-expression subtype (P=0.381) and basal-like subtype (P=0.282). Thyroid peroxidase antibody was an independent predictor for the low prevalence of axillary lymph node metastasis in breast cancer patients with luminal A subtype and luminal B subtype.

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Data Availability

The datasets used and/or analyzed during the current study were available from the corresponding author on reasonable request.

Code Availability

Not applicable.

Abbreviations

TPO-ab:

thyroid peroxidase antibody

TG-ab:

thyroglobulin antibody

TSHR-ab:

thyrotropin receptor antibody

CLT:

chronic lymphocytic thyroiditis

RFS:

relapse-free survival

OS:

overall survival

ALNM:

axillary lymph node metastasis

BMI:

body mass index

HR:

hormone receptor

ER:

estrogen receptor

PR:

progesterone receptor

HER2:

human epidermal growth factor receptor-2

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Acknowledgements

We appreciated all pathologists in this study.

Funding

This work was supported by the Shandong Provincial Natural Fund Committee [ZR2017MH 113 to H.J] and Youth Research Fund of the Affiliated Hospital of Qingdao University [2018-qdfy-3066 to L.X]. The second funder was the Affiliated Hospital of Qingdao University; our hospital provided financial support for all young outstanding researchers, hoping to achieve excellent findings and contribute to human health.

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Author notes

  1. Xiaoyi Liu and Zhengju Fu contributed equally to this work.

Authors and Affiliations

  1. The Center of Breast Disease, The Affiliated Hospital of Qingdao University, No.1677, Wutaishan Road, Qingdao, 266000, Shandong, China

    Xiaoyi Liu

  2. Department of Endocrinology, The Affiliated Hospital of Qingdao University, No. 16, Jiangsu Road, Qingdao, 266003, Shandong, China

    Zhengju Fu

  3. Department of Anesthesiology, The Affiliated Hospital of Qingdao University, No. 16, Jiangsu Road, Qingdao, 266003, Shandong, China

    Hongmei Xu

  4. The Laboratory of Thyroid Disease, The Affiliated Hospital of Qingdao University, No.1677, Wutaishan Road, Qingdao, 266000, Shandong, China

    Kui Che & Jingwei Chi

  5. The Laboratory of Thyroid Disease, The Affiliated Hospital of Qingdao University, No. 16, Jiangsu Road, Qingdao, 266003, Shandong, China

    Jianxia Hu

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  1. Xiaoyi Liu
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Contributions

All authors contributed to the study conception and design. Material preparation, data collection, and analysis were performed by Zhengju Fu, Hongmei Xu, Kui Che, and Jingwei Chi. The first draft of the manuscript was written by Xiaoyi Liu and Jianxia Hu, and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Jianxia Hu.

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This retrospective study was approved by the Ethics Committee in the Affiliated Hospital of Qingdao University. This study conformed with the Code of Ethics of the World Medical Association (Declaration of Helsinki).

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The authors declare no competing interests.

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Liu, X., Fu, Z., Xu, H. et al. Expression of Thyroid Peroxidase Antibody, Thyroglobulin Antibody, and Thyrotropin Receptor Antibody in Breast Cancer and Their Associations with Clinical Characteristics of Breast Cancer. Indian J Surg 84 (Suppl 3), 619–626 (2022). https://doi.org/10.1007/s12262-021-02887-y

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  • DOI: https://doi.org/10.1007/s12262-021-02887-y

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