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Application of Neck Technetium Uptake of the Neck in Post-Operation PTC Patients for Detection of Forthcoming Iodine Ablation Response to Therapy

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Abstract

Thyroid remnant after thyroidectomy is a major predictor for future recurrence of thyroid cancers; for which assessment, the accuracy of imaging is not optimal. To evaluate the value of the technetium uptake in the neck compared with neck ultrasonography, this application is used to predict future recurrence of differentiated thyroid cancer (DTC). The neck technetium uptake (NTU) value was acquired 20 min after injection of 1 mCi technetium by a camera. Patients were scheduled for forthcoming iodine ablation. Baseline risk factors were collected. Patients were followed for 10.5 (7 to 12) months when the records of the whole body scan, thyroglobulin, anti-thyroglobulin, neck ultrasonography, and the history of repeated iodine and surgical treatments were collected. The correlation of NTU and recurrence were studied. Out of 73 participants, 63 patients completed the study with established recurrence status and a valid NTU assessment. Baseline lymph node invasion (34.6% vs 80.0%; all 41.9%), extra-thyroid extension (17.0% vs 50.0%; all 22.2%), and tumor size (2.3 ± 2.1 vs 5.2 ± 2.4; all 2.7 ± 2.4) were higher in patients with future recurrence. But the NTU was similar in subjects with and without recurrence (−0.2 ± 0.7 vs 1.7 ± 6.3; all 59 ± 5.3). NTU was significantly lower in subjects with surgeries more extensive than thyroidectomy (P = 0.03). Recurrence cannot be predicted by NTU, but NTU may be used as a surrogate factor to determine the extent and completeness of the thyroidectomy surgery.

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Funding

The research was done as a residency program/specialty thesis; Tehran University of Medical Sciences.

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Authors and Affiliations

  1. Department of Nuclear Medicine, Vali-asr Hospital, Tehran University of Medical Sciences, Tehran, 1419731351, Iran

    Saeed Farzanefar, Maryam Naseri & Mehrshad Abbasi

  2. Endocrine Research Center, Division of Endocrine, Vali-asr Hospital, Tehran University of Medical Sciences, Tehran, Iran

    Manouchehr Nakhjavani

  3. Research Institute for Nuclear Medicine, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran

    Mehraneh Marzban, Mohammad Eftekhari & Hajar Albooyeh

Authors
  1. Saeed Farzanefar
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  2. Manouchehr Nakhjavani
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  3. Mehraneh Marzban
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  4. Mohammad Eftekhari
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  5. Hajar Albooyeh
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  6. Maryam Naseri
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  7. Mehrshad Abbasi
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Contributions

SF participated in procedure installation and calculations, interpreted the data, and participated in paper preparation. MN supervised the clinical part of the study, interpreted the data, and co-conceived the study. MM participated in calculations, data gathering, and follow-up of patients and also participated in paper preparation. ME supervised and co-conceived the study. HA participated in data gathering, interpretation, and paper preparation. MN participated in data gathering, interpretation, and paper preparation. MA participated conceived the study, installed the procedure, performed the calculation, interpreted the data, and drafted the paper.

Corresponding author

Correspondence to Mehrshad Abbasi.

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Ethics Approval and Consent to Participate

All human studies have been approved by the Tehran University of Medical Sciences ethics committee and have therefore been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and all subsequent revisions.

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Informed consent was obtained from all individual participants included in the study.

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The authors declare no competing interest.

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Farzanefar, S., Nakhjavani, M., Marzban, M. et al. Application of Neck Technetium Uptake of the Neck in Post-Operation PTC Patients for Detection of Forthcoming Iodine Ablation Response to Therapy. Indian J Surg 84, 436–441 (2022). https://doi.org/10.1007/s12262-021-02840-z

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  • DOI: https://doi.org/10.1007/s12262-021-02840-z

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