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Botulinum Toxin Injection for the Treatment of the Recurrent Rectovaginal Fistulas in Combination with Surgical Repair

  • Surgical Techniques and Innovations
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Abstract

Rectovaginal fistula is abnormal connections between the vagina and rectum. Via this connection, the passages of flatus or stool from rectum to vagina occur. Patient history and physical examination are usually enough to make diagnosis of fistula. Although there are so many defined surgical options including sphincteroplasty, advanced flap, muscle interposition, fibrin glue, plugs, and closure of fistulas remain a challenging condition with the high rate failure of surgical repair In this study, we aim to report the results of a new treatment approach with the injection of botulinum toxin into lateral internal sphincter on the management of rectovaginal fistula in conjunction with the surgical repair. Between 2013 and 2019, 8 patients with recurrent rectovaginal fistula underwent 10 surgical repairs in conjunction with 100 units botulinum toxin injection. Results of these patients were analyzed. We have treated 8 patients with recurrent rectovaginal fistula. The etiology of fistula in our patients included obstetrical trauna (3 patients), radiotherapy and rectal surgery (2 patients), vaginal reconstruction (2 patients) and Crohn’s disease (1 patient). The median number of their previous operations was 1.5 (range, 1–3). The sizes of fistulas range from 0.5 × 1 to 2 × 3 cm. In our surgical intervention, at the end, all of them were closed (100%) successfully. Botulinum toxin injection into lateral internal sphincter can be used successfully in combination with surgical intervention for the treatment of the rectovaginal fistulas.

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Abbreviations

BMI:

body mass index

RVF:

rectovaginal fistula

TVR:

transvaginal repair

ERAF:

endorectal advancement flap

BTX:

botulinum toxin

RT:

radiation therapy

References

  1. Debeche-Adams TH, Bohl JL (2010) Rectovaginal fistulas. Clin Colon Rectal Surg. 23(2):99–103. https://doi.org/10.1055/s-0030-1254296

    Article  PubMed  PubMed Central  Google Scholar 

  2. Fu J, Liang Z, Zhu Y, Cui L, Chen W (2019) Surgical repair of rectovaginal fistulas: predictors of fistula closure. Int Urogynecol J. 30(10):1659–1665. https://doi.org/10.1007/s00192-019-04082-w

    Article  PubMed  PubMed Central  Google Scholar 

  3. Ryoo SB, Oh HK, Ha HK, Han EC, Kwon YH, Song I, Moon SH, Choe EK, Park KJ (2019) Outcomes of surgical treatments for rectovaginal fistula and prognostic factors for successful closure: a single-center tertiary hospital experiences. Ann Surg Treat Res. 97(3):149–156. https://doi.org/10.4174/astr.2019.97.3.149

    Article  PubMed  PubMed Central  Google Scholar 

  4. Das B, Snyder M (2016) Rectovaginal fistulae. Clin Colon Rectal Surg. 29(1):50–56. https://doi.org/10.1055/s-0035-1570393

    Article  PubMed  PubMed Central  Google Scholar 

  5. Goldaber KG, Wendel PJ, McIntire DD, Wendel GD Jr (1993) Postpartum perineal morbidity after fourth-degree perineal repair. Am J Obstet Gynecol 168(2):489–493

    Article  CAS  Google Scholar 

  6. Pinto RA, Peterson TV, Shawki S, Davila GW, Wexner SD (2010) Are there predictors of outcome following rectovaginal fistula repair? Dis Colon Rectum. 53(9):1240–1247. https://doi.org/10.1007/DCR.0b013e3181e536cb

    Article  PubMed  Google Scholar 

  7. Takano S, Boutros M, Wexner SD (2014) Gracilis transposition for complex perineal fistulas: ectovaginal fistula and rectourethral fistula. Dis Colon Rectum. 57(4):538. https://doi.org/10.1097/DCR.0000000000000093

    Article  PubMed  Google Scholar 

  8. Seow-Choen F, Seow-En I (2013) Martius flap for ano-vaginal fistula: a photographic step by step guide. Tech Coloproctol. 17(4):467–468. https://doi.org/10.1007/s10151-012-0855-0

    Article  CAS  PubMed  Google Scholar 

  9. Gottgens KW, Smeets RR, Stassen LP, Beets G, Breukink SO (2014) The disappointing quality of published studies on operative techniques for rectovaginal fistulas: a blueprint for a prospective multi-institutional study. Dis Colon Rectum 57(7):888–898. https://doi.org/10.1097/DCR.0000000000000147

    Article  PubMed  Google Scholar 

  10. Tozer PJ, Balmforth D, Kayani B, Rahbour G, Hart AL, Phillips RK (2013) Surgical management of rectovaginal fistula in a tertiary referral centre: many techniques are needed. Colorectal Dis. 15(7):871–877. https://doi.org/10.1111/codi.12114

    Article  CAS  PubMed  Google Scholar 

  11. Piekarski JH, Jereczek-Fossa BA, Nejc D, Pluta P, Szymczak W, Sek P et al (2008) Does fecal diversion offer any chance for spontaneous closure of the radiation-induced rectovaginal fistula? Int J Gynecol Cancer. 18(1):66–70. https://doi.org/10.1111/j.1525-1438.2007.00954.x

    Article  CAS  PubMed  Google Scholar 

  12. Hackert T, Klaiber U, Hinz U, Kehayova T, Probst P, Knebel P et al (2017) Sphincter of Oddi botulinum toxin injection to prevent pancreatic fistula after distal pancreatectomy. Surgery 161:1444–1450 [PubMed

    Article  Google Scholar 

  13. Pilkington SA, Bhome R, Welch RE, Ku F, Warden C, Harris S, Hicks J, Richardson C, Dudding TC, Knight JS, King AT, Mirnezami AH, Beck NE, Nichols PH, Nugent KP (2018) Bilateral versus unilateral botulinum toxin injections for chronic anal fissure: a randomised trial. Tech Coloproctol. 22(7):545–551. https://doi.org/10.1007/s10151-018-1821-2

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Pricolo VE, Shellito PC (1994) Surgery for radiation injury to the large intestine. Variables influencing outcome. Dis Colon Rectum 37:675–684

    Article  CAS  Google Scholar 

  15. Brown HW, Wang L, Bunker CH, Lowder JL (2012) Lower reproductive tract fistula repairs in inpatient US women, 1979-2006. Int Urogynecol J 23:403–410

    Article  Google Scholar 

  16. Maeda K, Koide Y, Hanai T, Sato H, Masumori K, Matsuoka H, Katsuno H (2015) The longterm outcome of transvaginal anterior levatorplasty for intractable rectovaginal fistula. Colorectal Dis 17:1002–1006

    Article  CAS  Google Scholar 

  17. Saclarides TJ (2002) Rectovaginal fistula. Surg Clin North Am 82:1261–1272

    Article  Google Scholar 

  18. Corte H, Maggiori L, Treton X, Lefevre JH, Ferron M, Panis Y (2015) Rectovaginal fistula: what is the optimal strategy?: an analysis of 79 patients undergoing 286 procedures. Ann Surg 262:855–860

    Article  Google Scholar 

  19. Sjoveian S, Vangen S, Mukwege D, Onsrud M (2011) Surgical outcome of obstetric fistula: a retrospective analysis of 595 patients. Acta Obstet Gynecol Scand 90:753–760

    Article  Google Scholar 

  20. Kniery KR, Johnson EK, Steele SR (2015) Martius flap for repair of recurrent rectovaginal fistulas. Dis Colon Rectum 58:1210

    Article  Google Scholar 

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Correspondence to Fahri Yetisir.

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Yetisir, F., Güzel, K. Botulinum Toxin Injection for the Treatment of the Recurrent Rectovaginal Fistulas in Combination with Surgical Repair. Indian J Surg 84, 190–194 (2022). https://doi.org/10.1007/s12262-021-02823-0

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