Skip to main content

Advertisement

Log in

Submucosal Endoscopic Resection of Rectal GEP-NETs Is Curative—a Case Series Analysis

  • Surgical Techniques and Innovations
  • Published:
Indian Journal of Surgery Aims and scope Submit manuscript

Abstract

Rectal neuroendocrine tumors are usually small-sized lesions detected incidentally by colonoscopy and their survival rate is high. In its treatment, endoscopic mucosal resection and endoscopic submucosal dissection are frequently used. In this study, we aimed to retrospectively evaluate the patients who underwent endoscopic resection due to rectal neuroendocrine tumor. Seven patients who underwent endoscopic resection due to rectal neuroendocrine tumor in gastroenterology surgery endoscopy unit between 2015 and 2019 were included in the study. The cases were evaluated in terms of age, gender, tumor size, histopathology result, complete excision, en bloc excision, performed procedure, complication, additional procedure, referral to surgery, number of follow-up, follow-up time, and recurrence. The mean lesion size was 1.14 (0.8–1.5) cm. Histopathology results of all cases were evaluated as grade 1 neuroendocrine tumor. Complete excision and en bloc excision were performed in all cases. No complications were observed in the cases. No recurrence was observed in the cases. Endoscopic submucosal dissection and endoscopic mucosal resection can be safely used with high complete excision rate and low possibility of complications if the lesion is below 1.5 cm, and there is no muscle layer invasion in rectal neuroendocrine tumors.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Modlin IM, Oberg K, Chung DC, Jensen RT, de Herder WW, Thakker RV, Caplin M, Delle Fave G, Kaltsas GA, Krenning EP, Moss SF, Nilsson O, Rindi G, Salazar R, Ruszniewski P, Sundin A (2008) Gastroenteropancreatic neuroendocrine tumours. Lancet Oncol 9(1):61–72

    Article  CAS  Google Scholar 

  2. Rindi G, Arnold R, Bosman F (2010) Nomenclature and classification of neuroendocrine neoplasms of the digestive system. In: Bosman FT, Carneiro F, Hruban RH (eds) WHO classification of tumours of the digestive system. IARC Press, Lyon, pp 13–14

    Google Scholar 

  3. Park SB, Kim HW, Kang DH, Choi CW, Kim SJ, Nam HS (2015) Advantage of endoscopic mucosal resection with a cap for rectal neuroendocrine tumors. World J Gastroenterol 21(31):9387–9393

    Article  Google Scholar 

  4. Sung HY, Kim SW, Kang WK, Kim SY, Jung CK, Cho YK, Park JM, Lee IS, Choi MG, Chung IS (2012) Long-term prognosis of an endoscopically treated rectal neuroendocrine tumor: 10-year experience in a single institution. Eur J Gastroenterol Hepatol 24(8):978–983

    Article  Google Scholar 

  5. Kim GU, Kim KJ, Hong SM, Yu ES, Yang DH, Jung KW, Ye BD, Byeon JS, Myung SJ, Yang SK, Kim JH (2013) Clinical outcomes of rectal neuroendocrine tumors ≤ 10 mm following endoscopic resection. Endoscopy. 45(12):1018–1023

    Article  Google Scholar 

  6. Kwaan MR, Goldberg JE, Bleday R (2008) Rectal carcinoid tumors: review of results after endoscopic and surgical therapy. Arch Surg 143(5):471–475

    Article  Google Scholar 

  7. Landry CS, Brock G, Scoggins CR, McMasters KM, Martin RC 2nd. (2008) A proposed staging system for rectal carcinoid tumors based on an analysis of 4701 patients. Surgery. 144(3):460–466

    Article  Google Scholar 

  8. Kim J, Kim JH, Lee JY, Chun J, Im JP, Kim JS (2018) Clinical outcomes of endoscopic mucosal resection for rectal neuroendocrine tumor. BMC Gastroenterol 18(1):77

    Article  Google Scholar 

  9. Basuroy R, Haji A, Ramage JK, Quaglia A, Srirajaskanthan R (2016) Review article: the investigation and management of rectal neuroendocrine tumours. Aliment Pharmacol Ther 44(4):332–345

    Article  CAS  Google Scholar 

  10. Ramage JK, De Herder WW, Delle Fave G, Ferolla P, Ferone D, Ito T, Ruszniewski P, Sundin A, Weber W, Zheng-Pei Z, Taal B (2016) Pascher a; Vienna consensus conference participants. ENETS consensus guidelines update for colorectal neuroendocrine neoplasms. Neuroendocrinology. 103(2):139–143

    Article  CAS  Google Scholar 

  11. Chen T, Yao LQ, Xu MD, Zhang YQ, Chen WF, Shi Q, Cai SL, Chen YY, Xie YH, Ji Y, Chen SY, Zhou PH, Zhong YS (2016) Efficacy and safety of endoscopic submucosal dissection for colorectal carcinoids. Clin Gastroenterol Hepatol 14(4):575–581

    Article  Google Scholar 

  12. Çolak Ş, Gürbulak B, Çakar E, Bektaş H (2018) Evaluation of endoscopic mucosal resection and endoscopic submucosal dissection in submucosal lesions of the colon and rectum. Wideochir Inne Tech Maloinwazyjne 13(4):448–453

    PubMed  PubMed Central  Google Scholar 

  13. Cunningham D, Atkin W, Lenz HJ, Lynch HT, Minsky B, Nordlinger B, Starling N (2010) Colorectal cancer. Lancet. 375(9719):1030–1047

    Article  Google Scholar 

  14. Spychalski M, Koptas W, Zelga P, Dziki A (2017) Role of endoscopic submucosal dissection in treatment of rectal gastroenteropancreatic neuroendocrine neoplasms. Prz Gastroenterol 12(1):17–21

    PubMed  Google Scholar 

  15. Park HW, Byeon JS, Park YS, Yang DH, Yoon SM, Kim KJ, Ye BD, Myung SJ, Yang SK, Kim JH (2010) Endoscopic submucosal dissection for treatment of rectal carcinoid tumors. Gastrointest Endosc 72(1):143–149

    Article  Google Scholar 

  16. Jeon JH, Cheung DY, Lee SJ, Kim HJ, Kim HK, Cho HJ, Lee IK, Kim JI, Park SH, Kim JK (2014) Endoscopic resection yields reliable outcomes for small rectal neuroendocrine tumors. Dig Endosc 26(4):556–563

    Article  Google Scholar 

  17. Niimi K, Goto O, Fujishiro M, Kodashima S, Ono S, Mochizuki S, Asada-Hirayama I, Konno-Shimizu M, Mikami-Matsuda R, Minatsuki C, Yamamichi N, Koike K (2012) Endoscopic mucosal resection with a ligation device or endoscopic submucosal dissection for rectal carcinoid tumors: an analysis of 24 consecutive cases. Dig Endosc 24(6):443–447

    Article  Google Scholar 

  18. Zhao ZF, Zhang N, Ma SR, Yang Z, Han X, Zhao YF, Gao F, Gong ZJ, Yang L (2012) A comparative study on endoscopy treatment in rectal carcinoid tumors. Surg Laparosc Endosc Percutan Tech 22(3):260–263

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Contributions

TD conceived and planned the experiments. AŞ developed the theory. TD carried out the experiment. AŞ wrote the manuscript with support from TD and EBB. All authors interpreted the data, revised it critically, and contributed to the final version of the manuscript.

Corresponding author

Correspondence to Abdullah Senlikci.

Ethics declarations

Conflict of Interest

The authors declare that they have no conflicts of interest.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Dalgic, T., Senlikci, A. & Bostanci, E.B. Submucosal Endoscopic Resection of Rectal GEP-NETs Is Curative—a Case Series Analysis. Indian J Surg 82, 927–929 (2020). https://doi.org/10.1007/s12262-020-02428-z

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12262-020-02428-z

Keywords

Navigation