Abstract
The aim of this study was to describe the rate of patients with an inappropriate venous thromboembolism (VTE) prophylaxis in a Department of Surgery, study the risk factors associated with an inappropriate VTE prophylaxis, and analyze the effect of a simple educational program to improve these results. A quasi-experimental study was performed. VTE prophylaxis was studied in a Department of Surgery. The results of this analysis were presented to the Staff of the Department. Then, prophylaxis was again studied to analyze if this simple educational program improved these results. Inappropriate prophylaxis was seen in nearly 40% of the patients, mainly due to a lack of prescription. Inappropriate prophylaxis was associated with advanced age, ASA, surgical patient, no same-day surgery, no discharged patients, and high VTE risk. In the multivariate analysis, only no same-day surgery was related to inappropriate prophylaxis. The educational program achieved a non-significant reduction of inappropriate prophylaxis (31.7% vs. 40.5%, p = 0.070). A high percentage of patients in the Department of Surgery had an inappropriate VTE prophylaxis, mainly due to the lack of prescription. A simple educational program improved VTE prophylaxis prescription, although this improvement was not statistically significant.
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Cohen AT, Agnelli G, Anderson FA, Arcelus JI, Bergqvist D, Brecht JG, Greer IA, Heit JA, Hutchinson JL, Kakkar AK, Mottier D, Oger E, Samama MM, Spannagl M, VTE Impact Assessment Group in Europe (VITAE). (2007) Venous thromboembolism (VTE) in Europe. The number of VTE events and associated morbidity and mortality. Thromb Haemost 98 (4):756–764
Prandoni P, Lensing AW, Cogo A, Cuppini S, Villalta S, Carta M, Cattelan AM, Polistena P, Bernardi E, Prins MH (1996) The long-term clinical course of acute deep venous thrombosis. Ann Intern Med 125(1):1–7
Thiyagarajah K, Ellingwood L, Endres K, Hegazi A, Radford J, Iansavitchene A, Lazo-Langner A (2019) Post-thrombotic syndrome and recurrent thromboembolism in patients with upper extremity deep vein thrombosis: a systematic review and meta-analysis. Thromb Res 174:34–39. https://doi.org/10.1016/j.thromres.2018.12.012
Virchow R (1858) Die cellularpathologie in ihrer Begrundung auf physiologische un pathologische Cewebelehre. A. Hirscheald, Berlin
Nicolaides A, Irving D, Pretzell M, Dupont P, Lewis J, Desai S, Douglas JN, Kakkar VV, Field ES (1973) The risk of deep-vein thrombosis in surgical patients. Br J Surg 60(4):312
Clagett GP, Reisch JS (1988) Prevention of venous thromboembolism in general surgical patients. Results of meta-analysis. Ann Surg 208(2):227–240
Prevention of fatal postoperative pulmonary embolism by low doses of heparin. An international multicentre trial (1975). Lancet 2 (7924):45–51
Arcelus Martinez JI, Ramos Rodriguez JL (2013) Prevención de la Enfermedad Tromboembólica Venosa en Cirugía General y del Aparato Digestivo. Asociación Española de Cirugía, Spain
Gould MK, Garcia DA, Wren SM, Karanicolas PJ, Arcelus JI, Heit JA, Samama CM (2012) Prevention of VTE in nonorthopedic surgical patients: antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest 141 (2 Suppl):e227S-e277S. doi:https://doi.org/10.1378/chest.11-2297
Afshari A, Ageno W, Ahmed A, Duranteau J, Faraoni D, Kozek-Langenecker S, Llau J, Nizard J, Solca M, Stensballe J, Thienpont E, Tsiridis E, Venclauskas L, Samama CM, ESA VTE Guidelines Task Force. (2018) European guidelines on perioperative venous thromboembolism prophylaxis: executive summary. Eur J Anaesthesiol 35 (2):77–83. doi:https://doi.org/10.1097/EJA.0000000000000729
Cohen AT, Tapson VF, Bergmann JF, Goldhaber SZ, Kakkar AK, Deslandes B, Huang W, Zayaruzny M, Emery L, Anderson FA Jr, ENDORSE Investigators. (2008) Venous thromboembolism risk and prophylaxis in the acute hospital care setting (ENDORSE study): a multinational cross-sectional study. Lancet 371 (9610):387–394. doi:https://doi.org/10.1016/S0140-6736(08)60202-0
Kahn SR, Lim W, Dunn AS, Cushman M, Dentali F, Akl EA, Cook DJ, Balekian AA, Klein RC, le H, Schulman S, Murad MH (2012) Prevention of VTE in nonsurgical patients: antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest 141 (2 Suppl):e195S-e226S. doi:https://doi.org/10.1378/chest.11-2296
Venclauskas L, Maleckas A, Arcelus JI, Force EVGT (2018) European guidelines on perioperative venous thromboembolism prophylaxis: surgery in the obese patient. Eur J Anaesthesiol 35(2):147–153. https://doi.org/10.1097/EJA.0000000000000703
American Society for M, Bariatric Surgery Clinical Issues C (2013) ASMBS updated position statement on prophylactic measures to reduce the risk of venous thromboembolism in bariatric surgery patients. Surg Obes Relat Dis 9(4):493–497. https://doi.org/10.1016/j.soard.2013.03.006
Woller SC, Stevens SM, Evans RS et al. (2016) Electronic alerts, comparative practitioner metrics, and education improves thromboprophylaxis and reduces thrombosis. Am J med 129 (10):1124 e1117-1126. doi:https://doi.org/10.1016/j.amjmed.2016.05.014
Beeler PE, Kucher N, Blaser J (2011) Sustained impact of electronic alerts on rate of prophylaxis against venous thromboembolism. Thromb Haemost 106(4):734–738. https://doi.org/10.1160/TH11-04-0220
Kahn SR, Morrison DR, Diendere G et al (2018) Interventions for implementation of thromboprophylaxis in hospitalized patients at risk for venous thromboembolism. Cochrane Database Syst Rev 4:CD008201. https://doi.org/10.1002/14651858.CD008201.pub3
Woller SC, Stevens SM, Evans RS, Wray D, Christensen J, Aston VT, Wayne M, Lloyd JF, Wilson EL, Elliott CG (2018) Electronic alerts, comparative practitioner metrics, and education improve thromboprophylaxis and reduce venous thrombosis in community hospitals. Res Pract Thromb Haemost 2(3):481–489. https://doi.org/10.1002/rth2.12119
Piazza G, Anderson FA, Ortel TL, Cox MJ, Rosenberg DJ, Rahimian S, Pendergast WJ, McLaren G, Welker JA, Akus JJ, Stevens SM, Elliott CG, Freeman AL, Patton WF, Dabbagh O, Wyman A, Huang W, Rao AF, Goldhaber SZ (2013) Randomized trial of physician alerts for thromboprophylaxis after discharge. Am J Med 126(5):435–442. https://doi.org/10.1016/j.amjmed.2012.09.020
Al-Hameed F, Al-Dorzi HM, Aboelnazer E (2014) The effect of a continuing medical education program on venous thromboembolism prophylaxis utilization and mortality in a tertiary-care hospital. Thromb J 12:9. https://doi.org/10.1186/1477-9560-12-9
Lau BD, Shaffer DL, Hobson DB, Yenokyan G, Wang J, Sugar EA, Canner JK, Bongiovanni D, Kraus PS, Popoola VO, Shihab HM, Farrow NE, Aboagye JK, Pronovost PJ, Streiff MB, Haut ER (2017) Effectiveness of two distinct web-based education tools for bedside nurses on medication administration practice for venous thromboembolism prevention: a randomized clinical trial. PLoS One 12(8):e0181664. https://doi.org/10.1371/journal.pone.0181664
Cardoso LF, Krokoscz DV, de Paiva EF, Furtado IS, Mattar J Jr, de Souza E Sá MM, de Lira AC (2016) Results of a venous thromboembolism prophylaxis program for hospitalized patients. Vasc Health Risk Manag 12:491–496. https://doi.org/10.2147/VHRM.S101880
Blom JW, Doggen CJ, Osanto S, Rosendaal FR (2005) Malignancies, prothrombotic mutations, and the risk of venous thrombosis. JAMA 293(6):715–722. https://doi.org/10.1001/jama.293.6.715
Al-Samkari H, Connors JM (2019) Managing the competing risks of thrombosis, bleeding, and anticoagulation in patients with malignancy. Blood Adv 3(22):3770–3779. https://doi.org/10.1182/bloodadvances.2019000369
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Cano-Valderrama, O., Cuñarro-López, Y., Laiz, B. et al. Inappropriate Venous Thromboembolism Prophylaxis in a General Surgery Department: Risk Factors and Improvement with a Simple Educational Program. Indian J Surg 82, 855–860 (2020). https://doi.org/10.1007/s12262-020-02148-4
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DOI: https://doi.org/10.1007/s12262-020-02148-4