Skip to main content

Advertisement

Log in

Management of Upper GI bleeding

  • Original Article
  • Published:
Indian Journal of Surgery Aims and scope Submit manuscript

Abstract

Upper gastrointestinal bleeding remains a major problem associated with high morbidity and mortality. Many decades ago, the mortality of upper GI bleed was extremely high .However, with better understanding of physiology of resuscitation and blood transfusion, mortality in upper G I bleed did drop substantially. Advent of diagnostic oesophago-gastro-duodenoscopy did raise expectation of reducing the mortality but it failed to do so. However, it did help in the diagnosis. When therapeutic endoscopy came to the fore in its management, mortality did reduce little further but it has not become still zero and is hovering around 2–15%. The management of UGI bleed can be divided into pre-endoscopic management which comprises of resuscitation and assessment, empirical medical therapy, endoscopy both for diagnosis and therapy ,interventional radiology, surgery and follow-up. The UGI bleed can broadly be divided into variceal and Non-variceal bleed and both conditions have different management strategies after initial similar treatment of resuscitation and assessment. There are scoring systems for severity stratification of upper G I bleed. Many new methods are now available for endo haemostasis.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Fallah MA, Prakash C, Edmundowicz S (2000) Acute gastrointestinal bleeding. Med Clin North Am 84:1183–1208

    Article  CAS  Google Scholar 

  2. Sánchez-Delgado J, Gené E, Suárez D et al (2011) Has H. pylori prevalence in bleeding peptic ulcer been underestimated? A meta-regression. Am J Gastroenterol 106(3):398–405

    Article  Google Scholar 

  3. Longstreth GF (1995) Epidemiology of hospitalization for acute upper gastrointestinal hemorrhage: a population-based study. Am J Gastroenterol 90(2):206–210

    CAS  PubMed  Google Scholar 

  4. Liu NJ et al (2007) Outcomes of bleeding peptic ulcers: a prospective study. J Gastroenterol Hepatol 23:e340–e347

    Article  Google Scholar 

  5. Hearnshaw SA et al (2011) Acute upper gastrointestinal bleeding in the UK: patient characteristics, diagnoses and outcomes in the 2007 UK audit. Gut 10:1327–1335

    Article  Google Scholar 

  6. Scottish Intercollegiate Guidelines Network (SIGN). Management of acute upper and lower gastrointestinal bleeding. September 2008. http://www.sign.ac.uk/assets/sign105.pdf (accessed 15/10/16)

  7. National Institute for Health and Care Excellence (NICE). Acute upper gastrointestinal bleeding in over 16s: management. June 2012. https://www.nice.org.uk/guidance/cg141 (accessed 15/10/16

  8. Gralnek I, Dumonceau J, Kuipers E et al (2015) Diagnosis and management of nonvariceal upper gastrointestinal hemorrhage: European Society of Gastrointestinal Endoscopy (ESGE) guideline. Endoscopy 47:1–46

    Google Scholar 

  9. Stanley AJ, Ashley R, Dalton HR et al (2009) Outpatient management of patients with low-risk upper-gastrointestinal haemorrhage: multicentre validation and prospective evaluation. Lancet 373:42–47

    Article  CAS  Google Scholar 

  10. Saltzman J, Tabak Y, Hyett B, Sun X, Travis AC, Johannes RS (2011) A simple risk score accurately predicts in-hospital mortality, length of stay, and cost in acute upper GI bleeding. Gastrointest Endosc 74:1215–1224

    Article  Google Scholar 

  11. Labenz J, Peitz U, Leusing C, Tillenburg B, Blum AL, Börsch G (1997) Efficacy of primed infusions with high dose ranitidine and omeprazole to maintain high intragastric pH in patients with peptic ulcer bleeding: a prospective randomised controlled study. Gut 40:36–41

    Article  CAS  Google Scholar 

  12. Kaviani MJ, Hashemi MR, Kazemifar AR et al (2003) Effect of oral omeprazole in reducing re-bleeding in bleeding peptic ulcer a prospective, double-blind, randomized clinical trial. Aliment Pharmacol Ther 17:211

    Article  CAS  Google Scholar 

  13. Rahman R, Nguyen D, Sohail U, Almashhrawi AA, Ashraf I, Puli SR, Bechtold ML (2016) Pre-endoscopic erythromycin administration in upper gastrointestinal bleeding: an updated meta-analysis and systematic review. Ann Gastroenterol 29:312–317

    PubMed  PubMed Central  Google Scholar 

  14. Imperial TF, Birgisson S (1997) Somatostatin or octreotide compared with H2 antagonists and placebo in the management of acute nonvariceal upper gastrointestinal haemorrhage: a metaanalysis. Ann intern Med 127:1067

    Google Scholar 

  15. National Confidential Enquiry into Patient Outcome and Death (NCEPOD) (2015) Time to get control? A review of the care received by patients who had a severe gastrointestinal haemorrhage. http://www.ncepod.org.uk/2015report1/downloads/TimeToGetControlFullReport.pdf (accessed 15/10/16)

  16. Forrest JA, Finlayson ND, Shearman DJ (1974) Endoscopy in gastrointestinal bleeding. Lancet 2:394

    Article  CAS  Google Scholar 

  17. Calvet X, Vergara M, Brullet E, Gisbert JP, Campo R (2004) Addition of a second endoscopic treatment following epinephrine injection improves outcome in high risk bleeding ulcers. Gastroenterology 126:441–450

    Article  Google Scholar 

  18. Sung J, Luo D, Wu J, Ching JY, Chan FK, Lau JY, Mack S, Ducharme R, Okolo P, Canto M, Kalloo A, Giday SA (2011) Early clinical experience of the safety and effectiveness of Hemospray in achieving hemostasis in patients with acute peptic ulcer bleeding. Endoscopy 43:291–295

    Article  CAS  Google Scholar 

  19. Lau J, Sung JJ, Lee KK, Yung MY, Wong SK, Wu JC, Chan FK, Ng EK, You JH, Lee CW, Chan AC, Chung SC (2000) Effect of intravenous omeprazole on recurrent bleeding after endoscopic treatment of bleeding peptic ulcers. N Engl J Med 343:310–316

    Article  CAS  Google Scholar 

  20. NICE (2014) Gastro-oesophageal reflux disease and dyspepsia in adults: investigation and management. https://www.nice.org.uk/guidance/cg184/chapter/1-recommendations#helicobacter-pylori-testing-and-eradication (accessed 15/10/16)

  21. Frattaroli FM, Casciani E, Spoletini D, Prolettini E, Nunziale A, Bertini et al (2009) Prospective study comparing multi detector row CT and endoscopy in acute gastrointestinal bleeding. World J Surg 33(10):2209–2217

    Article  Google Scholar 

  22. Nusbaum M, Baum S (1963) Radiographic demonstration of unknown sites of gastrointestinal bleeding. Surg Forum 14:374–375

    CAS  PubMed  Google Scholar 

  23. (2013) Endovascular management of nonvariceal upper gastrointestinal hemorrhage: Eur J Gastroenterol Hepatol 25(7)

  24. 1229–6929 eISSN 2005–8330. Korean J 2012:13. https://doi.org/10.3348/kjr.2012.13.S1.S31pISSN

  25. (2017) Management of acute upper GI bleeding. J R Coll Physicians Edinb 47:218–30

  26. Tripathi D, Stanley AJ, Hayes P, Patch D, Millson C, Mehrzad H, Austin A, Ferguson JW, Olliff SP, Hudson M, Christie JM, Clinical Services and Standards Committee of the British Society of Gastroenterology (2015) UK guidelines on the management of variceal haemorrhage in cirrhotic patients. Gut 64:1680–1704

    Article  Google Scholar 

  27. Panés J, Terés J, Bosch J et al (1988) Efficacy of balloon tamponade in treatment of bleeding gastric and esophageal varices. Results in 151 consecutive episodes. Dig Dis Sci 33:454–459

    Article  Google Scholar 

  28. McCarty T, Njei B (2016) Self-expanding metal stents for acute refractory esophageal variceal bleeding: a systematic review and meta- analysis. Dig Endosc 28:539–547

    Article  Google Scholar 

  29. Zheng M, Chen Y, Bai J, Zeng Q, You J, Jin R, Zhou X, Shen H, Zheng Y, du Z (2008) Transjugular intrahepatic portosystemic shunt versus endoscopic therapy in the secondary prophylaxis of variceal rebleeding in cirrhotic patients: meta-analysis update. J Clin Gastroenterol 42:507–516

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Sunil Kumar.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Algorithm for management of upper gastrointestinal bleeding

Algorithm for management of upper gastrointestinal bleeding

figure a

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Kumar, S., Verma, A. & Kumar T, A. Management of Upper GI bleeding. Indian J Surg 83 (Suppl 3), 672–681 (2021). https://doi.org/10.1007/s12262-019-02055-3

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12262-019-02055-3

Keywords

Navigation