Liver Three-Dimensional Reconstruction Accurately Predicts Remnant Liver Volume for HBV-Related Hepatocellular Carcinoma Prior to Hepatectomy
- 37 Downloads
Accurate prediction of future remnant liver volume preoperatively is vital to avoid posthepatectomy liver failure (PHLF). In this study, we evaluated the accuracy and efficiency of Myrian software for predicting resected liver volume and future remnant liver volume for hepatitis B virus (HBV)-related hepatocellular carcinoma prior to liver resection. Patients with HBV-related hepatocellular carcinoma undergoing liver three-dimensional CT reconstruction prior to or after hepatectomy were enrolled in this study. All three-dimensional reconstructions were completed by two observers (observers 1 and 2) separately. Resected specimen weights were obtained in the operating room after liver resection. The correlations between resected liver volume and resected specimen weights, planned remnant liver volume (RLV) and actual RLV were analyzed. Bland-Altman plots were used to assess interobserver variability between observers 1 and 2. A total of 42 patients were enrolled in the study, including 32 men and 10 women with a median age of 49 years. The mean time needed to perform complete volumetry in a patient was 20.8 ± 2.9 min and 23.7 ± 3.8 min for observers 1 and 2, respectively. The resected liver volume of observers 1 and 2 measured by Myrian software correlated strongly with the resected specimen weight (P < 0.0001, r = 0.980; P < 0.0001, r = 0.982, respectively). Pearson’s correlation analysis showed that the planned RLV had a strong positive correlation with the actual RLV for observers 1 and 2 (P < 0.0001, r = 0.957; P < 0.0001, r = 0.949, respectively). Low interobserver variability was observed between observers 1 and 2. Liver three-dimensional CT reconstruction can accurately predict resected liver volume and future remnant liver volume for HBV-related hepatocellular carcinoma prior to liver resection.
KeywordsLiver three-dimensional reconstruction Myrian software Resected liver volume Remnant liver volume Hepatocellular carcinoma
Compliance with Ethical Standards
Conflict of Interest
The authors declare no conflicts of interest.
- 4.Clavien PA, Petrowsky H, DeOliveira ML et al (2007) Strategies for safer liver surgery and partial liver transplantation. N Engl J Med 356:1545–1559Google Scholar
- 5.Shoup M, Gonen M, D'Angelica M et al (2003) Volumetric analysis predicts hepatic dysfunction in patients undergoing major liver resection. J Gastrointest Surg 7:325–330Google Scholar
- 7.Fonseca AL, Cha CH (2014) Hepatocellular carcinoma: a comprehensive overview of surgical therapy. J Surg Oncol 110:712–719Google Scholar
- 9.Hoekstra LT, de Graaf W, Nibourg GA et al (2013) Physiological and biochemical basis of clinical liver function tests. Ann Surg 257:27–36Google Scholar
- 14.Rahbari NN,Garden OJ, Padbury R et al (2011) Posthepatectomy liver failure: a definition and grading by the international study Group of Liver Surgery (ISGLS). Surgery 149:713–724Google Scholar
- 17.Dello SA, Stoot JH, van Stiphout RS et al (2011) Prospective volumetric assessment of the liver on a personal computer by nonradiologists prior to partial hepatectomy. World J Surg 35:386–392Google Scholar
- 20.Kim HJ, Kim CY, Park EK et al (2015) Volumetric analysis and indocyanine green retention rate at 15 min as predictors of post-hepatectomy liver failure. HPB (Oxford) 17(2):159–167Google Scholar