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The Effect of Helicobacter pylori on Gastric Cancer Treated with Adjuvant Chemotherapy After Curative Resection

Indian Journal of Surgery volume 77, pages 489–494 (2015)Cite this article

Abstract

Helicobacter pylori has been associated with diverse pathologies of varying severity. We investigated the H. pylori infection status and its association with the pathologic features and clinical outcomes in stage III gastric cancer patients treated with adjuvant therapy after curative resection. Between 2004 and 2009, the records of 76 consecutive patients were retrospectively reviewed. H. pylori infection was confirmed by examination of pathological specimen. The relationship between H. pylori and the clinicopathological features was analyzed by Fisher exact test, Student’s t test, and Kaplan-Meier method. Of the 76 patients, 16 patients (21.1 %) were confirmed for H. pylori infection. The median age was 59 years. Twenty-three patients received chemotherapy and remainder received chemoradiotherapy. H. pylori status did not correlate with the clinicopathologic features. It was greater in non-neoplastic tissue than the tumor tissue (21.1 vs 7.9 %). Median follow-up was 21 months. During this period, 88.2 % patients had experienced tumor recurrence, and 85.5 % patients had died. Recurrence was observed in 87.5 % patients and in 88.3 % patients in H. pylori-positive and H. pylori-negative patients, respectively (P = 0.92). Disease-free survival was 28.4 ± 7.9 months and overall survival was 31.5 ± 7.4 months in H. pylori-positive patients compared with 28.3 ± 3.7 and 33.2 ± 3.4 months, respectively, in H. pylori-negative patients. H. pylori infection status did not have effect on the overall or disease-free survival (p = 0.85 and P = 0.86), respectively. H. pylori status might not be useful as a prognostic and predictive factor for clinical outcomes.

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Conflict of Interest

All authors have declared no conflict of interest.

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Authors and Affiliations

  1. Department of General Surgery, Ankara Oncology Education and Research Hospital, 06200, Demetevler, Ankara, Turkey

    Sevim Turanli, Hakan Mersin & Ugur Berberoglu

  2. Department of Pathology, Ankara Oncology Education and Research Hospital, 06200, Demetevler, Ankara, Turkey

    Nazan Bozdogan

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  1. Sevim Turanli
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  2. Nazan Bozdogan
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  3. Hakan Mersin
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  4. Ugur Berberoglu
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Correspondence to Sevim Turanli.

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Turanli, S., Bozdogan, N., Mersin, H. et al. The Effect of Helicobacter pylori on Gastric Cancer Treated with Adjuvant Chemotherapy After Curative Resection. Indian J Surg 77, 489–494 (2015). https://doi.org/10.1007/s12262-015-1305-9

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  • DOI: https://doi.org/10.1007/s12262-015-1305-9

Keywords

  • Helicobacter pylori
  • Gastric carcinoma
  • Prognosis
  • Survival