Abstract
Resection is the only chance of cure for isolated liver metastases from colorectal cancer. In the case of extended parenchymal resections, one crucial point is the ischemic damage to the remnant liver. We report an alternative technique for extremely extended liver resections without total hilar clamping for borderline liver remnants. Two patients presented with invasion of the infrahepatic vena cava, both with an estimated live remnant ≤20 %. The crucial point of the technique is the absence of a portal triad clamping in under beating heart-extracorporeal circulation. In both patients resection margins were free of disease. No signs of liver insufficiency were noted. Survival was more than 2 years in both cases. We believe that aggressive treatment of liver colorectal metastases should be given to all suitable patients. This operation may be added to the techniques that can be offered to these patients.
Similar content being viewed by others
References
Pawlik TM, Shulick RD, Choti MA (2008) Expanding criteria for resectability of colorectal liver metastases. Oncologist 13:51–64
Fong Y, Fortner J, Sun RL et al (1999) Clinical score for predicting recurrence after hepatic resection for metastatic colorectal cancer: analysis of 1001 consecutive cases. Ann Surg 230:309–318, discussion 318–321
Shimada H, Tanaka K, Masui H et al (2004) Results of surgical treatment for multiple (> or =5 nodules) bi-lobar hepatic metastases from colorectal cancer. Langenbecks Arch Surg 389(2):114–121
Wicherts DA, de Haas RJ, Andreani P et al (2010) Impact of portal vein embolization on long-term survival of patients with primarily unresectable colorectal liver metastases. Br J Surg 97(2):240–250
Khatri VP, Petrelli NJ, Belghiti J (2005) Extending the frontiers of surgical therapy for hepatic colorectal metastases: is there a limit? J Clin Oncol 23(33):8490–8499
Ferrero A, Viganò L, Polastri R et al (2007) Postoprative liver dysfunction and future remnant liver: where is the limit? Results of a prospective study. World J Surg 31:1643–1651
Khan AZ, Morris-Stiff G, Makuuchi M (2009) Patterns of chemotherapy-induced hepatic injury and their implications for patients undergoing liver resection for colorectal liver metastases. J Hepatobiliary Pancreat Surg 16(2):137–144
Morris-Stiff G, Tan YM, Vauthey JN (2008) Hepatic complications following preoperative chemotherapy with oxaliplatin or irinotecan for hepatic colorectal metastases. Eur J Surg Oncol 34(6):609–614
Zorzi D, Laurent A, Pawlik TM et al (2007) Chemotherapy associated hepatotoxicity and surgery for colorectal liver metastases. Br J Surg 94(3):274–286
Gurusamy KS, Kumar Y, Pamecha V, et al (2009) Ischaemic pre-conditioning for elective liver resections performed under vascular occlusion. Cochrane Database Syst Rev (1):CD007629
Hemming AW, Reed AI, Fujita S et al (2008) Role for extending hepatic resection using an aggressive approach to liver surgery. J Am Coll Surg 206(5):870–875, discussion 875–878
Karoui M, Penna C, Amin-Ashem M et al (2006) Influence of preoperative chemotherapy on the risk of major hepatectomy for colorectal liver metastases. Ann Surg 243(1):1–7
Reinacher-Schick AC, Bechstein WO (2007) Colorectal liver metastases. Neoadjuvant chemotherapy: aspects of medical surgical oncology. Internist (Berl) 48(1):51–58
Belghiti J, Dousset B, Sauvanet A et al (1991) Preliminary results with “ex situ” surgery for hepatic tumors: an alternative between palliative treatment and liver transplantation? Gastroenterol Clin Biol 15(5):449–453
Azoulay D, Andreani P, Maggi U et al (2006) Combined liver resection and reconstruction of the supra-renal vena cava: the Paul Brousse experience. Ann Surg 244(1):80–88
Johnson ST, Blitz M, Kneteman N et al (2006) Combined hepatic and inferior vena cava resection for colorectal metastases. J Gastrointest Surg 10(2):220–226
Aoki T, Sugawara Y, Imamura H et al (2004) Hepatic resection with reconstruction of the inferior vena cava or hepatic confluence for metastatic liver tumor from colorectal cancer. J Am coll Surg 198(3):366–372
Gurusamy KS, Sheth H, Kumar Y, et al (2009) Methods of vascular occlusion for elective liver resections. Cochrane Database Syst Rev (1):CD007632
Rahbari NN, Koch M, Mehrabi A et al (2009) Portal triad clamping vs vascular exclusion for vascular control during hepatic resection: a systematic review and meta-analysis. J Gastrointest Surg 13(3):558–568
van Gulik TM, de Graaf W, Dinant S et al (2007) Vascular occlusion techniques during liver resection. Dig Surg 24(4):278–281
Azoulay D, Lucidi V, Andreani P et al (2006) Ischemic preconditioning for major liver resection under vascular total exclusion of the liver preserving the caval flow: a randomized prospective study. J Am Coll Surg 202(2):203–211
Petrowsky H, McCormasc L, Trujillo M et al (2006) A prospective, randomized, controlled trial comparing intermittent portal triad clamping versus ischemic preconditioning with continuous clamping in major liver resections. Ann Surg 244(6):921–928
myrniotis V, Theodoraki K, Arkadopoulos N et al (2006) Ischemic preconditioning versus intermittent vascular occlusion in liver resection performed under selective vascular exclusion: a prospective randomized study. Am J Surg 192(5):669–674
Oldhafer KJ, Fuchs J, Steinoff G et al (2000) Extended liver resection in small children under circulatory arrest and “low-flow” cardiopulmonary bypass. Chirurg 71(6):692–695
Sener SF, Winchester DJ, Votapaka TV et al (2002) Continuing experience with liver resection and vena cava reconstruction using cardiopulmonary bypass and hypotermic circulatory arrest. Am Surg 68(4):359–363
Hwang YJ, Chang BH, Kim JW et al (1999) Successful resection of cecal hepatic metastasis extending to the right side of the heart under cardiopulmonary bypass. J Hepatobiliary Pancreat Surg 6:320–323
Inafuku H, Morishima Y, Nagano T et al (2009) A three-decade experience of radical open ndovenectomy with pericardial patch graft for correction of Budd-Chiari syndrome. J Vasc Surg 50(3):590–593
Carrel T, Berdat P, Schmidli J (2000) Cardiopulmonar interventions during oncologic surgery: technical principles and mid-term survival. Vasa 29(2):133–137
Kuehnl A, Schmidt M, Hornung HM et al (2007) Resection of malignant tumors invading the vena cava: perioperative complications and long term follow-up. J Vasc Surg 46(3):533–540
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Polistina, F., Fabbri, A. & Ambrosino, G. Hepatic Colorectal Metastases Involving Infra-Hepatic Inferior Vena Cava in High Risk Patients for Extended Resection: An Alternative Method for Achieving Radical Resection in Patient with Borderline Liver Remnant. Indian J Surg 75, 220–225 (2013). https://doi.org/10.1007/s12262-012-0681-7
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12262-012-0681-7