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Impact of Supplementing Preoperative Intravenous Omega 3 Fatty Acids in Fish Oil on Immunomodulation in Elderly Patients Undergoing Hip Surgery

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Abstract

The aim of this study was to evaluate the immunomodulatory effects of supplementing intravenous omega-3 fatty acids in fish oil (IVFO) in elderly patients undergoing hip surgery. This was a single centre, randomized, controlled, comparative, phase IV study in elderly patients undergoing hip surgery. The subjects, within the age range of 50–90 years, were assigned randomly to the group receiving intravenous omega-3 fatty acids in fish oil (IVFO, Omegaven®) or the control group not receiving intravenous fish oil (n = 20 in each group). IL-6, IL-8, IL-10, and HS-CRP levels were the inflammatory markers assessed in this study. The within-group comparison was done by paired t-test and between-group comparison by unpaired t-test. At day 4, IL-6 values in the IVFO group decreased as compared to day 0. At day 4, IL-8 mean values increased for both IVFO and control groups. This increase was highly significant in the control group (P = 0.0182). IL 10 values decreased at day 4 and increased at day 8 in the IVFO group. Increase in HS-CRP levels was nonsignificant at day 4 in the IVFO group (P = 0.60) and significant at day 8 for the control group (P = 0.0084) as compared to day 0. Various biochemical parameters including albumin, protein, SGOT, SGPT, blood glucose, and urea values generated evidence regarding the safety profile of IVFO. This study suggests a role for IVFO in the short-term suppression of inflammatory mediators for patients undergoing hip surgery. However, further, larger trials may be needed to establish its definitive role in this patient population.

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Acknowledgments

The funding for this study was through an unrestricted grant from Fresenius Kabi. The authors are grateful for the assistance of Dr. Sadanand Kulkarni during the preparation of this article.

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Authors and Affiliations

  1. Department of Anaesthesia and Intensive Care, NIMS, Hyderabad, India

    Ramachandran Gopinath, Sreekanth Yelliboina & Madhavi Singh

  2. Department of Orthopaedics, NIMS, Hyderabad, India

    V. B. N. Prasad

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  1. Ramachandran Gopinath
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  2. Sreekanth Yelliboina
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  3. Madhavi Singh
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  4. V. B. N. Prasad
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Correspondence to Ramachandran Gopinath.

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Gopinath, R., Yelliboina, S., Singh, M. et al. Impact of Supplementing Preoperative Intravenous Omega 3 Fatty Acids in Fish Oil on Immunomodulation in Elderly Patients Undergoing Hip Surgery. Indian J Surg 75, 478–484 (2013). https://doi.org/10.1007/s12262-012-0543-3

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  • DOI: https://doi.org/10.1007/s12262-012-0543-3

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