Indian Journal of Surgery

, Volume 75, Supplement 1, pp 25–26 | Cite as

Sporadic Multifocal Malignant Peripheral Nerve Sheath Tumor—A Rare Presentation

Multifocal MPNST
  • J. B. LeenaEmail author
  • Hilda Fernandes
  • G. K. Swethadri
Case Report


Malignant peripheral nerve sheath tumors(MPNST) are uncommon neoplasms with an incidence of 0.001% in general population. Multifocality is a rare manifestation of MPNST . A case of a 65 year old patient who presented with multiple swellings involving the neck, extremity and back without associated neurofibromatosis is reported for its rarity of presentation.. Diagnosis was made by FNAC and confirmed by peroperative findings and histopathology.


Multifocal MPNST FNAC Histopathology 


  1. 1.
    Hruban RH, Shiu MH, Senie RT, Woodruff JM (1990) Malignant peripheral nerve sheath tumors of the buttock and lower extremity. A study of 43 cases. Cancer 66:1253–1265PubMedCrossRefGoogle Scholar
  2. 2.
    Hujala LK, Martikainen P, Minn H, Grenman IR (1993) Malignant nerve sheath tumors of the head and neck: four case studies and review of the literature. Eur Arch Otorhinolaryngol 250:379–382PubMedCrossRefGoogle Scholar
  3. 3.
    Kim DH, Murovik JA, Tiel RL, Moes G, Klein DG (2005) A series of 397 peripheral nerve sheath tumors. 30 year experience at Louisiana State University Health Sciences Centre. J Neurosurg 102(2):246–255PubMedCrossRefGoogle Scholar
  4. 4.
    Doorn PF, Molenaar WM, Buter J, Hoekstra HJ (1995) Malignant peripheral nerve sheath tumors in patients with and without neurofibromatosis. Eur J Surg Oncol 21:78–82PubMedCrossRefGoogle Scholar
  5. 5.
    Evans DG, Baser ME, McGaughran J, Sharif S, Howard E, Moran A (2002) Malignant peripheral nerve sheath tumors in neurofibromatosis1. J Med Genet 39:311–314PubMedCentralPubMedCrossRefGoogle Scholar
  6. 6.
    Wu CC, Peng HL, Su CT, Lu TN, Lee CC, Chen LK (2003) Mesenteric and retroperitoneal malignant peripheral nerve sheath tumors in a patient with neurofibromatosis type 1. Chin J Radiol 28:193–198Google Scholar
  7. 7.
    Asavamongkolkul A, Jiranantakan T, Waikakul S, Phompitaksa K, Muangsomboon S (2001) Malignant peripheral nerve sheath tumor with neurofibromatosis type 1: a 2-case report and review of the literature. J Med Assoc Thai 84:285–293PubMedGoogle Scholar
  8. 8.
    Gabhane SK, Kotwal MN, Bobhate KS (2009) Morphological spectrum of peripheral nerve sheath tumors: a series of 126 cases. IJPM 52(1):29–33Google Scholar
  9. 9.
    Ducatman BS, Scheithauer BW, Piepgras DG, Reiman HM, Ilstrup DM (1986) Malignant peripheral nerve sheath tumors: a clinicopathologic study of 120 cases. Cancer 57:2006–2021PubMedCrossRefGoogle Scholar
  10. 10.
    Kar M, Deo SV, Shukla NK, Malik A, Datta GS et al (2006) Malignant peripheral nerve sheath tumors (MPNST)—Clinicopathological study and treatment outcome of twenty-four cases. World J Surg Oncol 22:4–55Google Scholar

Copyright information

© Association of Surgeons of India 2011

Authors and Affiliations

  • J. B. Leena
    • 1
    Email author
  • Hilda Fernandes
    • 1
  • G. K. Swethadri
    • 1
  1. 1.Department of pathologyFather Muller Medical CollegeMangaloreIndia

Personalised recommendations