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Effect of Gas Bubbles on the Recovery Efficiency of Paclitaxel from Biomass of Taxus chinensis in Ultrasonic Extraction

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Abstract

The synergistic effect of introducing both ultrasonic cavitation bubbles and gas bubbles to the extraction of paclitaxel from Taxus chinensis biomass was investigated. The addition of gas bubbles to ultrasonic extraction significantly improved the extraction efficiency, confirming that ultrasonic cavitation bubbles and gas bubbles have a synergistic effect. Furthermore, an ultrasonic power of 250 W and a gas flow rate of 1.750 L/min could recover up to 94% of the paclitaxel from the biomass. In addition, as the ultrasonic power and gas flow rate increased, the extraction rate constant, the effective diffusion coefficient, and the mass transfer coefficient also increased. The efficiency of paclitaxel extraction was improved by the efficient crushing of the biomass facilitated by the synergistic effect of the ultrasonic cavitation bubbles and the gas bubbles.

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Acknowledgements

This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIT) (Grant Number: 2021R1A2C1003186).

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  1. Center for Future Sustainable Technology, Department of Chemical Engineering, Kongju National University, Cheonan, 31080, Korea

    Hyo-Jin Jeon & Jin-Hyun Kim

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  1. Hyo-Jin Jeon
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  2. Jin-Hyun Kim
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Correspondence to Jin-Hyun Kim.

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Jeon, HJ., Kim, JH. Effect of Gas Bubbles on the Recovery Efficiency of Paclitaxel from Biomass of Taxus chinensis in Ultrasonic Extraction. Biotechnol Bioproc E 28, 545–553 (2023). https://doi.org/10.1007/s12257-023-0023-6

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  • DOI: https://doi.org/10.1007/s12257-023-0023-6

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