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Protective Effects of Titanium Dioxide-based Emulsion after Short-term and Long-term Infrared-A Ray Irradiation on Skin Cells

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Abstract

To accurately evaluate the protective effects of titanium dioxide-based emulsion from infrared-A rays (IRA) irradiation in daily life, we assessed the harmful effects of natural level of IRA irradiation on human skin cells. Using a well-defined solar IRA simulator, short-term (less than seven days) IRA irradiation on fibroblasts at 34°C elicited an increase in the matrix metalloproteinase-1 (MMP1) mRNA level and decrease in the collagen type-1 α-1 (COL1A1) mRNA level. While short-term IRA exposure showed negligible effects on cell proliferation at 34°C, long-term (24 days) IRA irradiation significantly decreased the proliferation of fibroblasts at the same temperature. However, in the presence of heat stress at 43°C, short-term IRA exposure also elicited severe damage including reduction in cell proliferation and procollagen type 1 C-terminal peptide (PIP) level. In addition, formulated titanium dioxide-based emulsion (IRA protective cream; IRC) with an infrared-A protection factor value of ten could successfully protect cells from damage by short-term and long-term IRA exposures. In this study, we demonstrated that IRC reduces mild and severe damages elicited by natural level of IRA irradiation mimicking system after short-term and long-term exposures.

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Acknowledgements

This study was supported by a research agreement with the COSMAX, Republic of Korea. This study was also supported by the grant (NRF-2020R1A2B5B01001677) from the National Research Foundation funded by the Ministry of Education, Science and Technology. The authors declare no conflicts of interest. Neither ethical approval nor informed consent was required for this study.

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  1. Jun Yeong Kim, Su Ji Kim, and Gayoun You contributed equally to this work.

Authors and Affiliations

  1. Department of Bioscience and Biotechnology, Konkuk University, Seoul, 05029, Korea

    Jun Yeong Kim, Gayeon You, Eun Seo Choi, Joo Hang Lee & Hyejung Mok

  2. R&I center, COSMAX, Seongnam, 13486, Korea

    Su Ji Kim & Jun Bae Lee

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Protective Effects of Titanium Dioxide-based Emulsion after Short-term and Long-term Infrared-A Ray Irradiation on Skin Cells

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Kim, J.Y., Kim, S.J., You, G. et al. Protective Effects of Titanium Dioxide-based Emulsion after Short-term and Long-term Infrared-A Ray Irradiation on Skin Cells. Biotechnol Bioproc E 26, 595–605 (2021). https://doi.org/10.1007/s12257-020-0308-y

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