Biotechnology and Bioprocess Engineering

, Volume 23, Issue 5, pp 532–540 | Cite as

Kinetics and Mechanism of Ultrasound-assisted Extraction of Paclitaxel from Taxus chinensis

  • Kyung-Wan Yoo
  • Jin-Hyun KimEmail author
Research Paper


Batch experimental studies were carried out for the ultrasound-assisted extraction of paclitaxel from Taxus chinensis while varying parameters such as ultrasound power, extraction temperature and contact time. The extraction of the majority of the paclitaxel (~99%) was achieved from the biomass by a single extraction at 380W of ultrasound power for a period of 10 min. The kinetics data obtained for the paclitaxel extractions, and the dominant role played by intraparticle diffusion, were found to be in concordance with the pseudo-second-order model, and the intraparticle diffusion model respectively. The effective diffusion coefficient of paclitaxel (4.1882 × 10-13 ~ 5.7093 × 10-13 m2/s) and the mass transfer coefficient (4.705 × 10-8 ~ 14.1160 × 10-8 m/s) increased when the extraction temperature and ultrasound power were raised.


paclitaxel ultrasound-assisted extraction kinetics effective diffusion coefficient mass transfer coefficient 


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Copyright information

© The Korean Society for Biotechnology and Bioengineering and Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Chemical EngineeringKongju National UniversityCheonanKorea

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