Novel rhodanine derivatives are selective algicides against Microcystis aeruginosa
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In this study, a series of rhodanine derivatives containing various substituents was synthesized and tested for in vitro algicidal activity. Among the tested substituent groups, phenyl substituents with halogen groups showed good inhibitory potency. Furthermore, the compound with chlorine at the C2 position of the phenyl ring exhibited a higher algicidal effect than the compound with chlorine at the C3 position of the phenyl ring. Among the various rhodanine derivatives tested, 5-(2,4-dichlorobenzylidene)- rhodanine (compound 20) was the most potent inhibitor against M. aeruginosa with a lethal concentration 50 (LC50) value of 0.65 μM and Selenastrum capricornutum with an LC50 value of 0.82 μM. To verify the feasibility of their use in ecosystems, 25 h of acute ecotoxicity tests were carried out for three derivatives against Danio rerio and Daphnia magna. No mortality was observed in groups exposed to 2.0 μM of compound 20 after 100 h of exposure. Moreover, a survival rate of 100% was observed in D. magna exposed to 2 μM of compound 20 for 100 h. Overall, the results show that rhodanine derivatives are a possible method for controlling and inhibiting harmful algal blooms.
Keywordsalgicidal activity ecotoxicity harmful algae blooms rhodanine
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- 5.Boesch, D. F., D. M. Anderson, R. A. Horner, S. E. Shumway, P. A. Tester, and T. E. Whitledge (1997) NOAA Coastal Ocean Program Decision Analysis Series. p. 46. No. 10. NOAA Coastal Office, Sliver Spring, MD.Google Scholar
- 6.Shirota, A. (1989) Red tide problem and countermeasures. Int. J. Aquat. Fish Technol. 1: 195–223.Google Scholar
- 7.Choi, H. G., P. J. Kim, W. C. Lee, S. J. Yun, H. G. Kim, and H. J. Lee (1998) Removal efficiency of cochiodinium polykrikoides by Yellow Loess. J. Kor. Fish Soc. 31: 109–113.Google Scholar
- 8.Gumbo, R. J., G. Ross, and E. T. Cloete (2008) Biological control of microcystis dominated harmful algal blooms. Afr. J. Biotechnol. 7: 4765–4773.Google Scholar
- 13.Daniel, J., S. Jana, G. Jakub, S. Marie, M. Blahoslva, and T. Eva (2007) Effects of aqueous extracts from five species of the family Papaveraceae on selected aquatic organisms. Envir. Toxi. 480–486.Google Scholar
- 21.Shafii, N., M. Khoobi, M. Amini, A. Sakhteman, H. Nadri, A. Moradi, S. Emami, E. Saeedian Moghadam, A. Foroumadi, and A. Shafiee (2015) Synthesis and biological evaluation of 5-benzylidenerhodanine-3-acetic acid derivatives as AChE and 15-LOX inhibitors. J. Enz. Inhib. Med. Chem. 30: 389–395.CrossRefGoogle Scholar