Biotechnology and Bioprocess Engineering

, Volume 22, Issue 6, pp 679–685 | Cite as

Spirulina extract-impregnated alginate-PCL nanofiber wound dressing for skin regeneration

  • Jung Il Choi
  • Min Sik Kim
  • Goo Yong Chung
  • Hwa Sung ShinEmail author
Research Paper


In recent years, nanofibers have been developed and widely used in many products, such as cosmetics and medical supplies. They can be fabricated from various synthetic or natural polymers and attached to bioactive compounds. In previous research, polycaprolactone (PCL) nanofibers containing Spirulina extract were demonstrated to be effective on dermal wound healing in a rat model. In this study, we fabricated Spirulina extract-alginate PCL nanofibers using alginate, which has hydrophilic structures capable of holding large amounts of water, to support the backbone of the nanofibers. The morphological characteristics, hydrophilicity, water absorbance, skin adhesiveness, toxicity to human keratinocyte cells (HaCaT), and Spirulina extract emission over time were assessed. Alginate improved the efficacy of Spirulina PCL nanofibers in moisture maintenance and adhesion ability, which highly affected recovery in the rat skin wound model. In conclusion, Spirulina extract-alginate PCL nanofibers could be considered a promising candidate for wound care.


wound dressing skin regeneration alginate Spirulina polycaprolactone nanofiber 


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Copyright information

© The Korean Society for Biotechnology and Bioengineering and Springer-Verlag GmbH Germany, part of Springer Nature 2017

Authors and Affiliations

  • Jung Il Choi
    • 1
  • Min Sik Kim
    • 1
  • Goo Yong Chung
    • 1
  • Hwa Sung Shin
    • 1
    Email author
  1. 1.Department of Biological EngineeringInha UniversityIncheonKorea

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