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Hair growth effects of Laminaria japonica extract and growth factor mixture on a C57BL/6 mouse model

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Abstract

To develop a drug to treat hair loss, we evaluated the effects of Laminaria japonica extract mixed with growth factor. After topical application of the L. japonica growth factor mixture to a six-week-old C57BL/6 mouse model, analysis of hair re-growth was determined using a high-resolution hair analysis system, as well as, photographic and histologic analysis. Depilated areas were completely covered with fully-grown hair in all study groups (control group, L. japonica extract group, and L. japonica extract mixed with growth factor group) and the hair re-growth score was the highest in the group treated with L. japonica supplemented with insulin-like growth factor-1 (IGF-1). The width and length of the hair follicles showed a significant increase in the groups treated with L. japonica mixed with IGF-1, compared to the control groups. Groups treated with L. japonica mixed with growth factor showed significantly increased gene expression of IGF-1 and decreased expression of transforming growth factor (TGF)-β, compared to the control groups. We confirmed that IGF-1 was more effective in promoting hair growth than vascular endothelial growth factor (VEGF). Therefore, we suggest that L. japonica mixed with IGF-1 could successfully be used to treat patients with alopecia; however, clinical trials and additional studies on the side effects of the mixture are necessary.

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Authors and Affiliations

  1. Department of Plastic and Reconstructive Surgery School of Medicine, Catholic University of Daegu, Daegu, Korea

    Bong Moo Lee, Ki Soo Park, Yong Jig Lee, Eun Som Choi & Dae Hwan Park

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  1. Bong Moo Lee
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  2. Ki Soo Park
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  3. Yong Jig Lee
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  4. Eun Som Choi
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  5. Dae Hwan Park
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Correspondence to Dae Hwan Park.

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Lee, B.M., Park, K.S., Lee, Y.J. et al. Hair growth effects of Laminaria japonica extract and growth factor mixture on a C57BL/6 mouse model. Biotechnol Bioproc E 21, 175–182 (2016). https://doi.org/10.1007/s12257-016-0015-x

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  • DOI: https://doi.org/10.1007/s12257-016-0015-x

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