Heavy metals accumulate in organisms throughout the food chain and eventually end up in humans. Heavy metals can cause severe diseases and may even result in death. Therefore, concerns about heavy metal accumulation in marine organisms have increased in recent years. To determine solutions to this concern, the sensitive detection of heavy metals in marine organisms is required. Current detection techniques for heavy metals present in marine organisms have several limitations, such as complicated pre-treatment steps and a lengthy analysis time. Thus, there are increasing needs for the newly developed methods of detecting heavy metals in marine organisms. In this review, we focus here on (1) the current detection techniques available and (2) the application of newly emergent nanotechnology for the sensitive detection of heavy metals in marine organisms.
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Qin, F., G. Li, H. Xiao, Z. Lu, H. Sun, and R. Chen (2012) Largescale synthesis of bismuth hollow nanospheres for highly efficient Cr(VI) removal. Dalton Transact. 41: 11263–11266.
Wongsasuluk, P., S. Chotpantarat, W. Siriwong, and M. Robson (2014) Heavy metal contamination and human health risk assessment in drinking water from shallow groundwater wells in an agricultural area in Ubon Ratchathani province, Thailand. Environ. Geochem. Health 36: 169–182.
Williams, T. J., and R. Cavicchioli (2014) Marine metaproteomics: Deciphering the microbial metabolic food web. Trends Microbiol. 22: 248–260.
Akoto, O., F. B. Eshun, G. Darko, and E. Adei (2014) Concentrations and health risk assessments of heavy metals in fish from the Fosu Lagoon. Int. J. Environ Res. 8: 403–410.
Abida, H., S. Ruchaud, L. Rios, A. Humeau, I. Probert, C. De Vargas, S. Bach, and C. Bowler (2013) Bioprospecting marine plankton. Marine Drugs 11: 4594–4611.
Abdul Wahab, A. S., S. N. Syed Ismail, S. M. Praveena, and S. Awang (2014) Heavy metals uptake of water mimosa (Neptunia oleracea) and its safety for human consumption. Iran J. Public Health. 43: 103–111.
Woolston, C. (2014) Ocean biology: Marine dreams. Nature 516: 277–279.
Kim, S. K. (2014) Marine cosmeceuticals. J. Cosmetic Dermatol. 13: 56–67.
Bloch, J. F. and E. Tardieu-Guigues (2014) Marine biotechnologies and synthetic biology, new issues for a fair and equitable profit-sharing commercial use. Mar. Genom. 17: 79–83.
Martins, A., H. Vieira, H. Gaspar, and S. Santos (2014) Marketed marine natural products in the pharmaceutical and cosmeceutical industries: Tips for success. Marine Drugs 12: 1066–1101.
Gerwick, W. H. and B. S. Moore (2012) Lessons from the past and charting the future of marine natural products drug discovery and chemical biology. Chem. Biol. 19: 85–98.
Fusetani, N. (2010) Biotechnological potential of marine natural products. Pure Appl. Chem. 82: 17–26.
Jang, Y. P. (2009) Marine organisms have been an important resource for the drug discovery industry. Arch. Pharmacal. Res. 32: 1483–1484.
Jones, G. (2013) Marine biology: Coral animals combat stress with sulphur. Nature 502: 634–635.
Heymans, J. J., M. Coll, S. Libralato, L. Morissette, and V. Christensen (2014) Global patterns in ecological indicators of marine food webs: A modelling approach. PloS one. 9: e95845.
Ruiz-Guzman, J. A., J. L. Marrugo-Negrete, and S. Diez (2014) Human exposure to mercury through fish consumption: Risk assessment of riverside inhabitants of the urra reservoir, Colombia. Hum. Ecol. Risk Assess. 20: 1151–1163.
Vinodhini, R. and M. Narayanan (2008) Bioaccumulation of heavy metals in organs of fresh water fish Cyprinus earpio (Common carp). Int. J. Environ. Sci. Te. 5: 179–182.
Okyere, H., R. B. Voegborlo, and S. E. Agorku (2015) Human exposure to mercury, lead and cadmium through consumption of canned mackerel, tuna, pilchard and sardine. Food Chem. 179: 331–335.
Said, T. O., A. A. Omran, K. F. Fawy, and A. M. Idris (2014) Heavy Metals in Twelve Edible Marine Fish Species from Jizan Fisheries, Saudi Arabia: Monitoring and Assessment. Fresen Environ. Bull. 23: 801–809.
Liu, Y., Q. Fu, J. Gao, W. G. Xu, B. Yin, Y. Q. Cao, and W. H. Qin (2013) [Concentrations and safety evaluation of heavy metals in aquatic products of Yancheng, Jiangsu Province]. Huan jing ke xue= Huanjing kexue / [bian ji, Zhongguo ke xue yuan huan jing ke xue wei yuan hui "Huan jing ke xue" bian ji wei yuan hui.]. 34: 4081–4089.
Liu, J. L., X. R. Xu, S. Yu, H. Cheng, J. X. Peng, Y. G. Hong, and X. B. Feng (2014) Mercury contamination in fish and human hair from Hainan Island, South China Sea: Implication for human exposure. Environ. Res. 135: 42–47.
Cirillo, T., E. Fasano, V. Viscardi, A. Arnese, and R. Amodio-Cocchieri (2010) Survey of lead, cadmium, mercury and arsenic in seafood purchased in Campania, Italy. Food Additives & Contaminants. Part B, Surveillance 3: 30–38.
Park, J. S., S. Y. Jung, Y. J. Son, S. J. Choi, M. S. Kim, J. G. Kim, S. H. Park, S. M. Lee, Y. Z. Chae, and M. Y. Kim (2011) Total mercury, methylmercury and ethylmercury in marine fish and marine fishery products sold in Seoul, Korea. Food Additives & Contaminants. Part B, Surveillance 4: 268–274.
Antelo, L. T., C. Lopes, A. Franco-Uria, and A. A. Alonso (2012) Fish discards management: pollution levels and best available removal techniques. Marine Pollut. Bull. 64: 1277–1290.
Syakti, A. D., C. Demelas, N. V. Hidayati, G. Rakasiwi, L. Vassalo, N. Kumar, P. Prudent, and P. Doumenq (2015) Heavy metal concentrations in natural and human-impacted sediments of Segara Anakan Lagoon, Indonesia. Environ. Monit. Assess. 187: 4079.
Sowmya, R., K. P. Indumathi, S. Arora, V. Sharma, and A. K. Singh (2015) Detection of calcium based neutralizers in milk and milk products by AAS. J. Food Sci. Technol. 52: 1188–1193.
Lemos, V. A. and L. O. dos Santos (2014) A new method for preconcentration and determination of mercury in fish, shellfish and saliva by cold vapour atomic absorption spectrometry. Food Chem. 149: 203–207.
Ahmad, K., A. Azizullah, S. Shama, and M. N. Khattak (2014) Determination of heavy metal contents in water, sediments, and fish tissues of Shizothorax plagiostomus in river Panjkora at Lower Dir, Khyber Pakhtunkhwa, Pakistan. Environ. Monit. Assess. 186: 7357–7366.
Verleysen, E., E. Van Doren, N. Waegeneers, P. J. De Temmerman, M. Abi Daoud Francisco, and J. Mast (2015) TEM and SPICP-MS analysis of the release of silver nanoparticles from decoration of pastry. J. Agricult. Food Chem. 63: 3570–3578.
Liu, R., P. Wu, L. Yang, X. Hou, and Y. Lv (2014) Inductively coupled plasma mass spectrometry-based immunoassay: A review. Mass Spectrom. Rev. 33: 373–393.
Fernandez, Z. H., L. A. V. Rojas, A. M. Alvarez, J. R. E. Alvarez, J. A. dos Santos, I. P. Gonzalez, M. R. Gonzalez, N. A. Macias, D. L. Sanchez, and D. H. Torres (2015) Application of Cold Vapor-Atomic Absorption (CVAAS) Spectrophotometry and inductively coupled plasma-atomic emission spectrometry methods for cadmium, mercury and lead analyses of fish samples. Validation of the method of CVAAS. Food Control. 48: 37–42.
Perugini, M., P. Visciano, M. Manera, A. Zaccaroni, V. Olivieri, and M. Amorena (2014) Heavy metal (As, Cd, Hg, Pb, Cu, Zn, Se) concentrations in muscle and bone of four commercial fish caught in the central Adriatic Sea, Italy. Environ. Monitor. Assess. 186: 2205–2213.
Annibaldi, A., S. Illuminati, C. Truzzi, and G. Scarponi (2011) SWASV speciation of Cd, Pb and Cu for the determination of seawater contamination in the area of the Nicole shipwreck (Ancona coast, Central Adriatic Sea). Marine Pollut. Bull. 62: 2813–2821.
Meucci, V., L. Intorre, C. Pretti, S. Laschi, M. Minunni, and M. Mascini (2009) Disposable electrochemical sensor for rapid measurement of heavy metals in fish by square wave anodic stripping voltammetry (SWASV). Veterinary Res. Communicat. 33: 249–252.
Fu, F. and Q. Wang (2011) Removal of heavy metal ions from wastewaters: A review. J. Environ. Management. 92: 407–418.
Li, M., H. L. Gou, I. Al-Ogaidi, and N. Q. Wu (2013) Nanostructured Sensors for Detection of Heavy Metals: A Review. Acs. Sustain. Chem. Eng. 1: 713–723.
Long, F., A. Zhu, H. Shi, H. Wang, and J. Liu (2013) Rapid onsite/ in-situ detection of heavy metal ions in environmental water using a structure-switching DNA optical biosensor. Scientific Rep. 3: 2308.
Porchetta, A., A. Vallee-Belisle, K. W. Plaxco, and F. Ricci (2013) Allosterically tunable, DNA-based switches triggered by heavy metals. J. Am. Chem. Soc. 135: 13238–13241.
Wei, Y., B. Li, X. Wang, and Y. Duan (2014) A nano-graphite-DNA hybrid sensor for magnified fluorescent detection of mercury( II) ions in aqueous solution. The Anal. 139: 1618–1621.
Rajamani, S., M. Torres, V. Falcao, J. E. Gray, D. A. Coury, P. Colepicolo, and R. Sayre (2014) Noninvasive evaluation of heavy metal uptake and storage in micoralgae using a fluorescence resonance energy transfer-based heavy metal biosensor. Plant Physiol. 164: 1059–1067.
Li, M., Q. Wang, X. Shi, L. A. Hornak, and N. Wu (2011) Detection of mercury(II) by quantum dot/DNA/gold nanoparticle ensemble based nanosensor via nanometal surface energy transfer. Anal. Chem. 83: 7061–7065.
Wang, Y., L. Bao, Z. Liu, and D. W. Pang (2011) Aptamer biosensor based on fluorescence resonance energy transfer from upconverting phosphors to carbon nanoparticles for thrombin detection in human plasma. Anal. Chem. 83: 8130–8137.
Kikkeri, R., V. Padler-Karavani, S. Diaz, A. Verhagen, H. Yu, H. Cao, M. A. Langereis, R. J. De Groot, X. Chen, and A. Varki (2013) Quantum dot nanometal surface energy transfer based biosensing of sialic acid compositions and linkages in biological samples. Anal. Chem. 85: 3864–3870.
Krishnamurthy, S. and P. V. Kamat (2014) CdSe-graphene oxide light-harvesting assembly: Size-dependent electron transfer and light energy conversion aspects. Chemphyschem: A European J. Chem. Physics and Physical Chem. 15: 2129–2135.
Hu, L., X. Liu, A. Cecconello, and I. Willner (2014) Dual switchable CRET-induced luminescence of CdSe/ZnS quantum dots (QDs) by the hemin/G-quadruplex-bridged aggregation and deaggregation of two-sized QDs. Nano Lett. 14: 6030–6035.
Wang, G., C. Lim, L. Chen, H. Chon, J. Choo, J. Hong, and A. J. de Mello (2009) Surface-enhanced Raman scattering in nanoliter droplets: Towards high-sensitivity detection of mercury (II) ions. Anal. Bioanal. Chem. 394: 1827–1832.
Peng, H. I. and B. L. Miller (2011) Recent advancements in optical DNA biosensors: Exploiting the plasmonic effects of metal nanoparticles. The Anal. 136: 436–447.
Lee, S. J., and M. Moskovits (2011) Visualizing chromatographic separation of metal ions on a surface-enhanced Raman active medium. Nano Lett. 11: 145–150.
Yang, X., C. Shi, D. Wheeler, R. Newhouse, B. Chen, J. Z. Zhang, and C. Gu (2010) High-sensitivity molecular sensing using hollow-core photonic crystal fiber and surface-enhanced Raman scattering. J. Opt. Soc. Am. A. 27: 977–984.
Liu, J., I. White, and D. L. DeVoe (2011) Nanoparticle-functionalized porous polymer monolith detection elements for surfaceenhanced Raman scattering. Anal. Chem. 83: 2119–2124.
Huang, S. H. and D. H. Chen (2009) Rapid removal of heavy metal cations and anions from aqueous solutions by an aminofunctionalized magnetic nano-adsorbent. J. Hazardous Mat. 163: 174–179.
Guo, S., D. Li, L. Zhang, J. Li, and E. Wang (2009) Monodisperse mesoporous superparamagnetic single-crystal magnetite nanoparticles for drug delivery. Biomat. 30: 1881–1889.
Xin, X., Q. Wei, J. Yang, L. Yan, R. Feng, G. Chen, B. Du, and H. Li (2012) Highly efficient removal of heavy metal ions by aminefunctionalized mesoporous Fe3O4 nanoparticles. Chem. Eng. J. 184: 132–140.
Gogoi, N., M. Barooah, G. Majumdar, and D. Chowdhury (2015) Carbon dots rooted agarose hydrogel hybrid platform for optical detection and separation of heavy metal ions. ACS Appl. Mat. Interfaces. 7: 3058–3067.
Jaiswal, A., S. S. Ghosh, and A. Chattopadhyay (2012) One step synthesis of C-dots by microwave mediated caramelization of poly(ethylene glycol). Chem. Communicat. 48: 407–409.
Krajewska, B. (2001) Diffusion of metal ions through gel chitosan membranes. React. Funct. Polym. 47: 37–47.
Akhavan, B., K. Jarvis, and P. Majewski (2015) Plasma polymerfunctionalized silica particles for heavy metals removal. ACS Appl. Mat. Interfaces. 7: 4265–4274.
Wang, X. M., Y. F. Pei, M. X. Lu, X. Q. Lu, and X. Z. Du (2015) Highly efficient adsorption of heavy metals from wastewaters by graphene oxide-ordered mesoporous silica materials. J. Mater. Sci. 50: 2113–2121.
Sun, Y. X., Q. Hao, X. R. Xu, X. J. Luo, S. L. Wang, Z. W. Zhang, and B. X. Mai (2014) Persistent organic pollutants in marine fish from Yongxing Island, South China Sea: Levels, composition profiles and human dietary exposure assessment. Chemosphere. 98: 84–90.
Yavuz, C. T., J. T. Mayo, C. Suchecki, J. Wang, A. Z. Ellsworth, H. D'Couto, E. Quevedo, A. Prakash, L. Gonzalez, C. Nguyen, C. Kelty, and V. L. Colvin (2010) Pollution magnet: Nano-magnetite for arsenic removal from drinking water. Environ. Geochem. Health 32: 327–334.
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Jo, Y., Kim, K. & Choi, J. Perspectives on the nanotechnology applications of for the analytical detection of heavy metals in marine organisms. Biotechnol Bioproc E 21, 191–198 (2016). https://doi.org/10.1007/s12257-015-0737-1
- marine organisms
- heavy metals