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Effect of cubic phase nanoparticle on obesity-suppressing efficacy of herbal extracts

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Abstract

The adipocyte differentiation-inhibiting efficacies of cubic phase nanoparticle/herbal extract mixture suspensions were much higher than those of herbal extract suspensions (grape, apple, mugwort, barberry root, and green tea). Confocal laser scanning microscopy and fluorescenceactivated cell sorting analysis revealed that cubic phase nanoparticle promoted the internalization of a watersoluble dye (e.g. calcein) into adipocyte cell. Cubic phase nanoparticle/herbal extract mixture suspensions decreased the blood contents of aspartate aminotransferase, total cholesterol, triglyceride, urea nitrogen, and low density lipoprotein more than herbal extract suspensions. Cubic phase nanoparticle also promoted the efficacy of the herbal extracts in suppressing the body weight gain and the liver weight of rats. The amount permeated through hairless mouse skin was higher when cubic phase nanoparticle was included in barberry root extract suspension.

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References

  1. Hong, S. K., J. Y. Ma, and J. -C. Kim (2012) In vitro skin permeation enhancement of KIOM-MA-128 by Monoolein Cubosomes. J. Disper. Sci. Technol. 33: 1503–1508.

    Article  CAS  Google Scholar 

  2. Mishra, N., N. P. Yadav, J. G. Meher, and P. Sinha (2012) Phytovesicles: Conduit between conventional and novel drug delivery system. Asian Pac. J. Trop. Biomed. 2: S1728–S1734.

    Article  Google Scholar 

  3. Kwon, T. K. and J. -C. Kim (2010) In vitro skin permeation of monoolein nanoparticles containing hydroxypropyl beta-cyclodextrin/ minoxidil complex. Int. J. Pharm. 392: 268–273.

    Article  CAS  Google Scholar 

  4. Kwon, T. K., S. K. Hong, and J. -C. Kim (2012) In vitro skin permeation of cubosomes containing triclosan. J. Ind. Eng. Chem. 18: 563–587.

    Article  CAS  Google Scholar 

  5. Esposito, E., R. Cortesi, M. Drechsler, L. Paccamiccio, P. Mariani, C. Contado, E. Stellin, E. Menegatti, F. Bonina, and C. Puglia (2005) Cubosome dispersions as delivery systems for percutaneous administration of indomethacin. Pharmaceut. Res. 22: 2163–2173.

    Article  CAS  Google Scholar 

  6. Kwon, T. K. and J. -C. Kim (2010) Preparation and in vitro skin permeation of cubosomes containing hinokitiol. J. Disper. Sci. Technol. 31: 1004–1009.

    Article  CAS  Google Scholar 

  7. Seo, S. R., G. Kang, J. W. Ha, and J. -C. Kim (2013) In vivo hair growth-promoting efficacies of herbal extracts and their cuboso-mal suspensions. J. Ind. Eng. Chem. 19: 1331–1339.

    Article  CAS  Google Scholar 

  8. Zhao, X. Y., J. Zhang, L. Q. Zheng, and D. H. Li (2005) Studies of cubosomes as a sustained drug delivery system. J. Disper. Sci. Technol. 25: 795–799.

    Article  Google Scholar 

  9. Baskaran, T. R., R. K. Thapa, J. Y. Rhyu, H. Y. Choi, J. O. Kim, C. S. Yong, and B. K. Yoo (2012) Design and in-vitro evaluation of finasteride-loaded liquid crystalline nanoparticles for topical delivery. AAPS Pharm. Sci. Tech. 14: 45–52.

    Google Scholar 

  10. Kwon, T. K., H. Y. Lee, J. -D. Kim, W. C. Shin, S. K. Park, and J. -C. Kim (2010) In vitro skin permeation of cubosomes containing water soluble extracts of Korean barberry. Colloid J. 72: 205–210.

    Article  CAS  Google Scholar 

  11. Fang, J. Y., S. Y. Yu, P. C. Wu, Y. B. Huang, and Y. H. Tsai (2001) In vitro skin permeation of estradiol from various proniosome formulations. Int. J. Pharm. 215: 91–99.

    Article  CAS  Google Scholar 

  12. Bao, Y., S. Zhang, and W. Shi (2012) Percutaneous absorption effects of Chinese herbal medicine. Afr. J. Pharm. Pharmaco. 6: 389–396.

    Google Scholar 

  13. Nariya, M., V. Shukia, S. Jain, and B. Bavishankar (2009) Comparison of enteroprotective efficacy of triphala formulations (Indian Herbal Drug) on methotrexate-induced small intestinal damage in rats. Phytother. Res. 23: 1092–1098.

    Article  Google Scholar 

  14. Um, J. Y., H. Chung, K. S. Kim, I. C. Kwon, and S. Y. Jeong (2003) In vitro cellular interaction and absorption of dispersed cubic particles. Int. J. Pharm. 253: 71–80.

    Article  CAS  Google Scholar 

  15. Boyd, B. J., S. B. Rizwan, Y. D. Dong, S. Hook, and T. Rades (2007) Self-assembled geometric liquid-crystalline nanoparticles imaged in three dimensions: Hexosomes are not necessarily flat hexagonal prisms. Langmui. 23: 12461–12464.

    Article  CAS  Google Scholar 

  16. Nguyen, T. H., T. Hanley, C. J. H. Proter, and B. J. Boyd (2011) Nanostructured liquid crystalline particles provide long duration sustained-release effect for a poor water soluble drug after oral administration. J. Control. Releas. 153: 180–186.

    Article  CAS  Google Scholar 

  17. Rattanapak. T., K. Young, T. Rades, and S. Hook (2012) Comparative study of liposomes, transfersomes, ethosomes and cubosomes for transcutaneous immunisation: Characterisation and in vitro skin penetration. J. Pharm. Pharmacol. 64: 1560–1569.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. College of Biomedical Science and Institute of Bioscience and Biotechnology, Kangwon National University, Chuncheon, 200-701, Korea

    Ju Hyup Lee & Jin-Chul Kim

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  1. Ju Hyup Lee
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  2. Jin-Chul Kim
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Correspondence to Jin-Chul Kim.

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Lee, J.H., Kim, JC. Effect of cubic phase nanoparticle on obesity-suppressing efficacy of herbal extracts. Biotechnol Bioproc E 20, 1005–1015 (2015). https://doi.org/10.1007/s12257-015-0417-1

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  • DOI: https://doi.org/10.1007/s12257-015-0417-1

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