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The double-edged sword of immune checkpoint inhibition in advanced staged thymic epithelial tumours

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References

  1. Katsuya Y, Fujita Y, Horinouchi H, et al. Immunohistochemical status of PD-L1 in thymoma and thymic carcinoma. Cancer Treat Res. 2015;88:154–9.

    Google Scholar 

  2. Bedekovics J, Beke L, Mokanszki A, et al. Programmed death-ligand 1 (PD-L1) expression in Thymic epithelial tumors. Appl Immunohistochem Mol Morphol. 2020;28:1–9.

    Article  CAS  Google Scholar 

  3. Weissferdt A, Fujimoto J, Kalhor N, et al. Expression of PD‑1 and PD-L1 in thymic epithelial neoplasms. Mod Pathol. 2017;30:826–33.

    Article  CAS  Google Scholar 

  4. Giaccone G, Kim C, Thompson J, et al. Pembrolizumab in patients with thymic carcinoma: a single-arm, single-centre, phase 2 study. Lancet Oncol. 2018;19:347–55.

    Article  CAS  Google Scholar 

  5. Cho J, Kim HS, Ku BM, et al. Pembrolizumab for patients with refractory or relapsed Thymic epithelial tumor: an open-label phase II trial. J Clin Oncol. 2019;37:2162–70.

    Article  CAS  Google Scholar 

  6. Rajan A, Heery CR, Thomas A, et al. Efficacy and tolerability of anti-programmed death-ligand 1 (PD-L1) antibody (Avelumab) treatment in advanced thymoma. J Immunother Cancer. 2019;7:269.

    Article  Google Scholar 

  7. Shen L, Chen H, Wei Q. Immune-therapy-related toxicity events and dramatic remission after a single dose of pembrolizumab treatment in metastatic thymoma: a case report. Front Immunol. 2021;12:621858.

    Article  CAS  Google Scholar 

  8. Konstantina T, Konstantinos R, Anastasios K, et al. Fatal adverse events in two thymoma patients treated with anti-PD‑1 immune check point inhibitor and literature review. Cancer Treat Res. 2019;135:29–32.

    Google Scholar 

  9. Katsuya Y, Horinouchi H, Seto T, et al. Single-arm, multicentre, phase II trial of nivolumab for unresectable or recurrent thymic carcinoma: PRIMER study. Eur J Cancer. 2019;113:78–86.

    Article  CAS  Google Scholar 

  10. Merveilleux du Vignaux C, Dansin E, Mhanna L, et al. Systemic therapy in advanced Thymic epithelial tumors: insights from the RYTHMIC prospective cohort. J Thorac Oncol. 2018;13:1762–70.

    Article  Google Scholar 

  11. Zander T, Aebi S, Rast AC, et al. Response to pembrolizumab in a patient with relapsing Thymoma. J Thorac Oncol. 2016;11:e147–e9.

    Article  Google Scholar 

  12. Chen Q, Huang DS, Zhang LW, et al. Fatal myocarditis and rhabdomyolysis induced by nivolumab during the treatment of type B3 thymoma. Clin Toxicol. 2018;56:667–71.

    Article  CAS  Google Scholar 

  13. Girard N, Merveilleux du Vignaux C. Systemic treatment for thymic malignancies. Curr Opin Oncol. 2017;29:112–7.

    Article  Google Scholar 

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Correspondence to Wolfgang Jungraithmayr MD PhD.

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W. Jungraithmayr declares that he has no competing interests.

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Jungraithmayr, W. The double-edged sword of immune checkpoint inhibition in advanced staged thymic epithelial tumours. memo 14, 373–375 (2021). https://doi.org/10.1007/s12254-021-00737-x

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  • DOI: https://doi.org/10.1007/s12254-021-00737-x

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